Participant number
High (24 mg/ml) Vs Low Cond (6mg/ml)
Morning, Lunch or Afternoon session under high strength
Morning, Lunch or Afternoon session under low strength
Baseline salivary cotinine levels (taken 2 weeks prior to lab session)
Baseline 3_Hydroxy-Cotinine levels (taken 2 weeks prior to lab sessions)
3 hydroxy cotinine divided by cotinine (rounded to 2pd)
Highest_Qualification
Device used the most
Current Brand / model
What strengths do you use
What strength do you use the most
Estimate of how much e-liquid used per day
How soon after you wake up do you use your ecig
Do you find it difficult to refrain from using your e-cig in places where it is forbidden
Which puffs on your e-cig would you hate most to give up
Do you puff more frequently on your e-cig during the first hours after waking than during the rest of the day
Do you use your e-cig if you are so ill that you are in bed most of the day
Please rate your addiction on a scale of 0 to 100
For you stopping using the e-cig for good would be
How much of the time have you felt the urge to vape
How strong have the urges to vape been
Since you started using the e-cig, have you attempted to cut down the amount that you use it
If yes, in you attempt to cut down, how succesful have you been
Is it likely that in one month now, you will have stopped using the e-cig
Adapted FTND scores items number 7 to 11 from Ecig use questionnaire
Grand total of Items 7 to 13 from the E-cig use questionnaire
description from participant
baseline CO level for the 24mg/ml condition
baseline CO level for the 6mg/ml condition
Nicotine concentration in plasma in ng/mL under 24mg/ml cond. at baseline
Nicotine concentration in plasma in ng/mL under 24mg/ml cond. at 10mins after first puff
Nicotine concentration in plasma in ng/mL under 24mg/ml cond. at 30 minutes
Nicotine concentration in plasma in ng/mL under 24mg/ml cond. at 60 minutes
Nicotine concentration in plasma in ng/mL under 6 mg/ml cond. at baseline
Nicotine concentration in plasma in ng/mL under 6 mg/ml cond. at 10mins after first puff
Nicotine concentration in plasma in ng/mL under 6 mg/ml cond. at 30mins after first puff
Nicotine concentration in plasma in ng/mL under 6 mg/ml cond. at 60mins after first puff
volume (ml) of e-liquid consumed in the 24mg/ml condition
volume (ml) of e-liquid consumed in the 6mg/ml condition
Total Number of puffs taken under high strength
Number of puffs taken at 10 minutes after first puff under high cond
Non-cumulative Number of puffs taken between 10 and 30 minutes under high cond
Non-cumulative Number of puffs taken between 30 and 60 minutes under high cond
Cumulative Number of puffs taken at 30 minutes after first puff under high cond
Cumulative Number of puffs taken at 60 minutes after first puff under high cond
Mean duration of total puffs taken under high strength
Mean duration of puffs taken at 10 minutes under high strength
Mean duration of puffs taken at 30 minutes under high strength
Mean duration of puffs taken at 60 minutes under high strength
Coil resistance recorded by E-Vic supreme
Wattage recorded by E-Vic supreme set up at 3.9V
Total Number of puffs taken under low strength
Number of puffs taken at 10 minutes after first puff under low strength
Non cumulative Number of puffs taken between 10 and 30 minutes under low strength
Non cumulative Number of puffs taken between 30 and 60 minutes under low strength
Cumulative Total Number of puffs taken at 30 minutes after first puff under low strength
Cumulative Total Number of puffs taken at 60 minutes after first puff under low strength
Mean duration of puffs taken at 10 minutes
Mean duration of puffs taken at 30 minutes
Mean duration of puffs taken at 60 minutes
Mean duration of total puffs taken under low strength
How strong is your urge to vape right now at baseline under 24mg/ml
How strong is your urge to vape right now at 10 mins after first puff under 24 mg/ml
How strong is your urge to vape right now at 30 mins under 24mg/ml
How strong is your urge to vape right now at 60 mins under 24mg/ml
Differences in urge to vape between baseline and 60 minutes under 24mg/ml
How strong is your urge to vape right now at baseline under 6mg/ml
How strong is your urge to vape right now at 10 mins after frist puff under 6mg/ml
How strong is your urge to vape right now at 30 mins under 6mg/ml
How strong is your urge to vape right now at 60 mins under 6mg/ml
Differences in urge to vape between baseline and 50 mins under 6mg/ml
High condition: MPSS depression rating at baseline
High condition: MPSS irritability rating at baseline
High condition: MPSS anxiety rating at baseline
High condition: MPSS drowy rating at baseline
High condition: MPSS restlessness rating at baseline
High condition: MPSS hungry rating at baseline
High condition: MPSS unable to concentrate rating at baseline
High condition: Total MPSS rating at baseline
High condition: MPSS depression rating at 10 mins
High condition: MPSS irritability rating at 10 mins
High condition: MPSS anxiety rating at 10 mins
High condition: MPSS drowy rating at 10 mins
High condition: MPSS restlessness rating at 10 mins
High condition: MPSS hungry rating at 10 mins
High condition: MPSS unable to concentrate rating at 10 mins
High condition: Total MPSS rating at 10 mins
High condition: MPSS depression rating at 30 mins
High condition: MPSS irritability rating at 30 mins
High condition: MPSS anxiety rating at 30 mins
High condition: MPSS drowy rating at 30 mins
High condition: MPSS restlessness rating at 30 mins
High condition: MPSS hungry rating at 30 mins
High condition: MPSS unable to concentrate rating at 30 mins
High condition: Total MPSS rating at 30 mins
High condition: MPSS depression rating at 60 mins
High condition: MPSS irritability rating at 60 mins
High condition: MPSS anxiety rating at 60 mins
High condition: MPSS drowy rating at 60 mins
High condition: MPSS restlessness rating at 60 mins
High condition: MPSS hungry rating at 60 mins
High condition: MPSS unable to concentrate rating at 60 mins
High condition: Total MPSS rating at 60 mins
High condition: Change in total MPSS scores from baseline to 60 mins
Low condition: MPSS depression rating at baseline
Low condition: MPSS irritability rating at baseline
Low condition: MPSS anxiety rating at baseline
Low condition: MPSS drowy rating at baseline
Low condition: MPSS restlessness rating at baseline
Low condition: MPSS hungry rating at baseline
Low condition: MPSS unable to concentrate rating at baseline
Low condition: Total MPSS rating at baseline
Low condition: MPSS depression rating at 10 mins
Low condition: MPSS irritability rating at 10 mins
Low condition: MPSS anxiety rating at 10 mins
Low condition: MPSS drowy rating at 10 mins
Low condition: MPSS restlessness rating at 10 mins
Low condition: MPSS hungry rating at 10 mins
Low condition: MPSS unable to concentrate rating at 10 mins
Low condition: Total MPSS rating at 10 mins
Low condition: MPSS depression rating at 30 mins
Low condition: MPSS irritability rating at 30 mins
Low condition: MPSS anxiety rating at 30 mins
Low condition: MPSS drowy rating at 30 mins
Low condition: MPSS restlessness rating at 30 mins
Low condition: MPSS hungry rating at 30 mins
Low condition: MPSS unable to concentration rating at 30 mins
Low condition: Total MPSS rating at 30 mins
Low condition: MPSS depression rating at 60 mins
Low condition: MPSS irritability rating at 60 mins
Low condition: MPSS anxiety rating at 60 mins
Low condition: MPSS drowy rating at 60 mins
Low condition: MPSS restlessness rating at 60 mins
Low condition: MPSS hungry rating at 60 mins
Low condition: MPSS unable to concentrate rating at 60 mins
Low condition: Total MPSS rating at 60 mins
Low condition: Change in total MPSS scores from baseline to 60 mins
I feel a definite hit from the e-cigarette under 24mg/ml
The e-cigarette is satisfying under 24mg/ml
The e-cigarette is pleasant under 24mg/ml
The e-cigarette tastes good under 24mg/ml
The e-cigarette has reduced my craving for nicotine under 24mg/ml
The e-cigarette has helped my concentration under 24mg/ml
The e-cigarette has made me feel calmer under 24mg/ml
The e-cigarette has made me feel more awake under 24mg/ml
The e-cigarette has reduced my hunger under 24mg/ml
The e-cigarette tastes like my usual brand/model under 24mg/ml
The e-cigarette feels like using my usual brand/model under 24mg/ml
High VAS negative effects: confused
High VAS negative effects: dizzy
High VAS negative effects: headache
High VAS negative effects: pounding heart
High VAS negative effects:light headed
High VAS negative effects: feeling sick
High VAS negative effects: nervous
High VAS negative effects: salivation
High VAS negative effects: sweaty
High VAS negative effects: feeling weak
High VAS negative effects: mouth irritation
High VAS negative effects: throat irritation
High VAS negative effects: aching jaws
High VAS negative effects: vomiting
High VAS negative effects: bloating
High VAS negative effects: stomach ache
High VAS negative effects: heartburn
High VAS negative effects: diarrhoea
HIgh VAS negative effects: hiccups
High VAS negative effects: cold hands/feet
High VAS negative effects: heart palpitations
Low VAS positive effects: I feel a definite hit from the e-cigarette under 6mg/ml
Low VAS positive effects: The e-cigarette is satisfying under 6mg/ml
Low VAS positive effects: The e-cigarette is pleasant under 6mg/ml
Low VAS positive effects: The e-cigarette tastes good under 6mg/ml
Low VAS positive effects: The e-cigarette has reduced my craving for nicotine under 6mg/ml
Low VAS positive effects: The e-cigarette has helped my concentration under 6mg/ml
Low VAS positive effects: The e-cigarette has made me feel calmer under 6mg/ml
Low VAS positive effects: The e-cigarette has made me feel more awake under 6mg/ml
Low VAS positive effects: the e-cigarette has reduced my hunger under 6mg/ml
Low VAS positive effects: The e-cigarette tastes like my usual brand/model under 6mg/ml
Low VAS positive effects: The e-cigarette feels like using my usual brand/model under 6mg/ml
Low VAS negative effects: confused
Low VAS negative effects: dizzy
Low VAS negative effects: headache
Low VAS negative effects: pounding heart
Low VAS negative effects:light headed
Low VAS negative effects: feeling sick
Low VAS negative effects: nervous
Low VAS negative effects: salivation
Low VAS negative effects: sweaty
Low VAS negative effects: feeling weak
Low VAS negative effects: mouth irritation
Low VAS negative effects: throat irritation
Low VAS negative effects: aching jaws
Low VAS negative effects: vomiting
Low VAS negative effects: bloating
Low VAS negative effects: stomach ache
Low VAS negative effects: heartburn
Low VAS negative effects: diarrhoea
Low VAS negative effects: hiccups
Low VAS negative effects: cold hands/feet
Low VAS negative effects: heart palpitations
mean total adverse effects in high nic condition
mean total adverse effects in the low nic condition
Nicotine boost at 10 min under high cond (Plasma concentrations taken from 10min minus baseline)
Nicotine boost at 30 min under high cond (Plasma concentrations taken from 30min minus baseline)
Nicotine boost at 10 min under high cond (Plasma concentrations taken from 60min minus baseline)
Nicotine boost at 10 min under low cond (Plasma concentrations taken from 10min minus baseline)
Nicotine boost at 30 min under low cond (Plasma concentrations taken from 30min minus baseline)
Nicotine boost at 60 min under low cond (Plasma concentrations taken from 60min minus baseline)
Change scores at 10 minutes under high
Change scores at 30 minutes under high
Change scores at 60 minutes under high
Change scores at 10 minutes under low
Change scores at 30 minutes under low