The Evidence Base for Psychological Interventions for Rheumatoid Arthritis: A Systematic Review of Reviews


Prothero, Louise, Barley, Elizabeth, Galloway, James, Georgopoulou, S. and Sturt, Jackie 2018. The Evidence Base for Psychological Interventions for Rheumatoid Arthritis: A Systematic Review of Reviews. International Journal of Nursing Studies. 82, pp. 20-29.
AuthorsProthero, Louise, Barley, Elizabeth, Galloway, James, Georgopoulou, S. and Sturt, Jackie


Psychological interventions are an important but often overlooked adjunctive treatment option for patients with rheumatoid arthritis. Findings from systematic reviews of psychological interventions for this patient group are conflicting. A systematic review of reviews can explain inconsistencies between studies and provide a clearer understanding of the effects of interventions.

To: 1) determine the effectiveness of psychological interventions in improving biopsychosocial outcomes for adults with rheumatoid arthritis, 2) determine the relationship between the intensity of the psychological interventions (number of sessions, duration of sessions, duration of intervention) on outcomes, and 3) assess the impact of comparator group (usual care, education only) on outcomes.

We conducted a systematic review of reviews using the following inclusion criteria: 1) randomised controlled trials of psychological interventions (including cognitive behavioural therapy, supportive counselling, psychotherapy, self-regulatory techniques, mindfulness-based cognitive therapy and disclosure therapy) provided as an adjunct to medication, 2) included rheumatoid arthritis patients aged ≥ 18 years, 3) reported findings for at least 1 of the primary outcomes: pain, fatigue, psychological status, functional disability and disease activity and 4) were published in English between January 2000 and March 2015 (updated
Data sources

We searched in MEDLINE, EMBASE, CINAHL, PsycINFO, the Cochrane Database of Systematic Reviews and the Database of Abstracts of Reviews of Effects. Reference lists were searched for additional reviews.
Review methods

Study selection and 50% of the quality assessments were performed by two independent reviewers. Methodological quality was measured using the Assessment of Multiple Systematic Reviews checklist. Data extraction was conducted by one reviewer using a predesigned data extraction form.

Eight systematic reviews met inclusion criteria (one review was excluded due to its low-quality score). Small post intervention improvements in patient global assessment, functional disability, pain, fatigue, anxiety and depression were observed. The effect on coping, self-efficacy and physical activity was greater. Improvements in depression, coping and physical activity were maintained (8.5–14 months). Interventions delivered over a longer period with a maintenance component appeared more effective. Attention, education, and placebo control groups produced some improvements but not as large as those produced by the psychological interventions.

Psychological interventions result in small to moderate improvements in biopsychosocial outcomes for patients with rheumatoid arthritis in addition to those achieved by standard care. Several priorities for future research were identified, including determining the cost effectiveness of non-psychologically trained health professionals delivering psychological interventions.

AMSTAR, Assessment of Multiple Systematic Reviews; CBT, cognitive behavioural therapy; MIm, otivational interviewing; OMERACT, outcome measures in rheumatology; OT, occupational therapy; RA, rheumatoid arthritis; RCT, randomized controlled trial; TAU, treatment as usual

JournalInternational Journal of Nursing Studies
Journal citation82, pp. 20-29
PublisherElsevier for Pergamon
Accepted author manuscript
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Publication dates
Online13 Mar 2018
Publication process dates
Deposited14 Mar 2018
Accepted09 Mar 2018
Accepted09 Mar 2018
FunderNational Institute for Health Research
King’s College Hospital Charity
Copyright holder© 2018 The Authors
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