A Model for the Regulation of Lipopolysaccharide Synthesis during Outer Membrane Biogenesis in Escherichia Coli
Emiola, A. 2015. A Model for the Regulation of Lipopolysaccharide Synthesis during Outer Membrane Biogenesis in Escherichia Coli. PhD Thesis University of East London Health, Sport and Bioscience
The role of systems biology in the interpretation and analysis of important biological events is gaining rapid acceptance in a number of biological fields. Here a computational systems approach was applied to investigate the production and regulation of Escherichia coli’s (E. coli) outer membrane. The outer membrane comprises of phospholipids in the inner leaflet, and lipopolysaccharides (LPS) in the outer leaflet. LPS is an endotoxin that elicits a strong immune response from humans and its biosynthesis is in part, regulated via degradation of LpxC and WaaA enzymes by the protease FtsH. Despite a substantial amount of research conducted on LPS synthesis, there is remarkably little information on its regulation.
|Digital Object Identifier (DOI)||doi:10.15123/PUB.4802|
|Publication process dates|
|Deposited||17 Feb 2016|
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