Effect of age-related ventilatory inefficiency on respiratory sensation during exercise

Article


Faisal, A., Webb, Katherine A., Guenette, Jordan A., Jensen, Dennis, Neder, J. Alberto and O’Donnell, Denis E. 2014. Effect of age-related ventilatory inefficiency on respiratory sensation during exercise. Respiratory Physiology & Neurobiology. 205, pp. 129-139.
AuthorsFaisal, A., Webb, Katherine A., Guenette, Jordan A., Jensen, Dennis, Neder, J. Alberto and O’Donnell, Denis E.
Abstract

To examine the effect of age-related respiratory function impairment on exertional dyspnea, we compared ventilatory and perceptual responses to incremental exercise under control (CTRL) and added dead space (DS) loading conditions in healthy fit older (55–79 years) and younger (20–39 years) men. Older individuals had higher ventilatory equivalents for CO2 throughout exercise (p < 0.05) suggesting greater ventilatory inefficiency but operating lung volumes were similar compared to younger individuals. With added DS compared to CTRL, both groups similarly increased tidal volume (by 0.3–0.6 L) and ventilation (by 8–13 L/min) at submaximal work rates (each p < 0.05). At peak exercise with DS, both groups failed to further increase ventilation and had small reductions in peak work rate (p < 0.05). Increases in dyspnea intensity ratings with the addition of DS were similar at standardized submaximal work rates in older and younger groups. We conclude that, despite differences in ventilatory efficiency, the respiratory–mechanical and sensory responses to added chemostimulation during exercise were similar in fit older and younger individuals.

JournalRespiratory Physiology & Neurobiology
Journal citation205, pp. 129-139
ISSN15699048
Year2014
PublisherElsevier
Digital Object Identifier (DOI)doi:10.1016/j.resp.2014.10.017
Web address (URL)https://doi.org/10.1016/j.resp.2014.10.017
Publication dates
Print04 Nov 2014
Publication process dates
Deposited13 Sep 2017
Copyright information© 2014 Elsevier
Permalink -

https://repository.uel.ac.uk/item/85874

  • 4
    total views
  • 0
    total downloads
  • 1
    views this month
  • 0
    downloads this month

Related outputs

Increased respiratory neural drive and work of breathing in exercise-induced laryngeal obstruction
Walsted, Emil Schwarz, Faisal, A., Jolley, Caroline J., Swanton, Laura L., Pavitt, Matthew J., Luo, Yuan-Ming, Backer, Vibeke, Polkey, Michael I. and Hull, James H. 2017. Increased respiratory neural drive and work of breathing in exercise-induced laryngeal obstruction. Journal of Applied Physiology. 124 (2), pp. 356-363.
Unraveling the Cause of Severe Exertional Dyspnea in a Heavy Smoker
Elbehairy, Amany F., Hockmann, Karlo, Ciavaglia, Casey E., Faisal, A., Hill, Elizabeth, Webb, Katherine A., Neder, J. Alberto and O’Donnell, Denis E. 2017. Unraveling the Cause of Severe Exertional Dyspnea in a Heavy Smoker. Annals of the American Thoracic Society. 14 (12), pp. 1849-1855.
Effective Bronchoscopic Lung Volume Reduction Accelerates Exercise Oxygen Uptake Kinetics in Emphysema
Faisal, A., Zoumot, Zaid, Shah, Pallav L., Neder, J. Alberto, Polkey, Michael I. and Hopkinson, Nicholas S. 2016. Effective Bronchoscopic Lung Volume Reduction Accelerates Exercise Oxygen Uptake Kinetics in Emphysema. Chest. 149 (2), pp. 435-446.
Resting Physiological Correlates of Reduced Exercise Capacity in Smokers with Mild Airway Obstruction
Elbehairy, Amany F., Faisal, A., Guenette, Jordan A., Jensen, Dennis, Webb, Katherine A., Ahmed, Rashid, Neder, J. Alberto and O'Donnell, Denis E. 2017. Resting Physiological Correlates of Reduced Exercise Capacity in Smokers with Mild Airway Obstruction. COPD: Journal of Chronic Obstructive Pulmonary Disease. 14 (3), pp. 267-275.