Gender differences and age-specific associations between Body Mass Index and other cardiovascular risk factors in CMV infected and uninfected people

Article


Terrazzini, N., Bajwa, Martha, Thomas, David, Smith, Helen and Kern, Florian 2014. Gender differences and age-specific associations between Body Mass Index and other cardiovascular risk factors in CMV infected and uninfected people. Immunology Letters. 162 (1 B), pp. 316-322.
AuthorsTerrazzini, N., Bajwa, Martha, Thomas, David, Smith, Helen and Kern, Florian
Abstract

Recent studies have highlighted Body Mass Index (BMI) as an important parameter
associated with cardiovascular risk and cancer.
Here we have explored the relationship between BMI and other cardiovascular risk factors
such as white blood count (WBC) and mean arterial blood pressure (MAP) in young (20-35
years) and older (60-85 years) healthy donors stratified by gender and CMV IgG serostatus.
We found a positive correlation between BMI and WBC in young women, which was
significant in CMV+ women. Interestingly, there was a non-significant opposite trend in
young men. In older women the positive trend was preserved in the presence of CMVinfection,
but no clear trend was seen in older men. Gender differences were also observed
by opposite trends regarding an association between MAP and WBC (positive in young
women, negative in young men). These associations were not observed at older ages.
However, in CMV+ older men, there was a significant association between MAP and WBC
as well as neutrophil count (NC). CRP values were only available in older participants, and
interestingly, correlated with WBC and NC only in women, and more closely in CMVwomen.
This study reveals that the correlations between common inflammatory
markers/cardiovascular risk factors depend on age, gender, and CMV infection status in a
complex fashion. Our findings support the need to evaluate risk factors independently in men
and women and to take into account CMV infection status. More focused studies will be
required to shed light on these novel findings.

JournalImmunology Letters
Journal citation162 (1 B), pp. 316-322
ISSN0165-2478
Year2014
PublisherElsevier
Accepted author manuscript
License
CC BY-ND
Web address (URL)http://dx.doi.org/10.1016/j.imlet.2014.09.011
Publication dates
Print19 Sep 2014
Publication process dates
Deposited29 Sep 2014
Accepted2014
Copyright informationNOTICE: this is the author’s version of a work that was accepted for publication in Immunology Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version will be published in Immunology Letters, with the doi:10.1016/j.imlet.2014.09.010.
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