Up-Beat UK: A programme of research into the relationship between coronary heart disease and depression in primary care patients.

Article

Tylee, Andre, Ashworth, Mark, Barley, Elizabeth, Brown, June, Chambers, John, Farmer, Anne, Fortune, Zoe, Haddad, Mark, Lawton, Rebecca, Mann, Anthony, Mehay, A., McCrone, Paul, Murray, Joanne, Leese, Morven, Pariante, Carmine, Rose, Diana, Rowlands, Gill, Smith, Alison and Walters, Paul 2011. Up-Beat UK: A programme of research into the relationship between coronary heart disease and depression in primary care patients. BMC Family Practice. 12 (38). https://doi.org/10.1186/1471-2296-12-38
AuthorsTylee, Andre, Ashworth, Mark, Barley, Elizabeth, Brown, June, Chambers, John, Farmer, Anne, Fortune, Zoe, Haddad, Mark, Lawton, Rebecca, Mann, Anthony, Mehay, A., McCrone, Paul, Murray, Joanne, Leese, Morven, Pariante, Carmine, Rose, Diana, Rowlands, Gill, Smith, Alison and Walters, Paul
Abstract

BACKGROUND:
Coronary heart disease and depression are both common health problems and by 2020 will be the two leading causes of disability worldwide. Depression has been found to be more common in patients with coronary heart disease but the nature of this relationship is uncertain. In the United Kingdom general practitioners are now being remunerated for case-finding for depression in patients with coronary heart disease, however it is unclear how general practitioners should manage these patients. We aim to explore the relationship between coronary heart disease and depression in a primary care population and to develop an intervention for patients with coronary heart disease and depression.

METHODS/DESIGN:
This programme of research will consist of 4 inter-related studies. A 4 year prospective cohort study of primary care patients with coronary heart disease will be conducted to explore the relationship between coronary heart disease and depression. Within this, a nested case-control biological study will investigate genetic and blood-biomarkers as predictors of depression in this sample. Two qualitative studies, one of patients' perspectives of treatments for coronary heart disease and co-morbid depression and one of primary care professionals' views on the management of patients with coronary heart disease and depression will inform the development of an intervention for this patient group. A feasibility study for a randomised controlled trial will then be conducted.

DISCUSSION:
This study will provide information on the relationship between coronary heart disease and depression that will allow health services to determine the efficiency of case-finding for depression in this patient group. The results of the cohort study will also provide information on risk factors for depression. The study will provide evidence on the efficacy and feasibility of a joint patient and professional led intervention and data necessary to plan a definitive randomised controlled trial of the intervention.

JournalBMC Family Practice
Journal citation12 (38)
Year2011
PublisherBMC
Publisher's version
License
CC BY
Digital Object Identifier (DOI)https://doi.org/10.1186/1471-2296-12-38
Web address (URL)https://doi.org/10.1186/1471-2296-12-38
Publication dates
Online23 May 2011
Publication process dates
Deposited29 Oct 2018
Accepted23 May 2011
Accepted23 May 2011
FunderNational Institute for Health Research
Copyright information© 2011 Tylee et al; licensee BioMed Central Ltd. 2011
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