Differential patterns of histone acetylation in inflammatory bowel diseases

Article


Tsaprouni, Loukia G., Ito, Kazuhiro, Powell, Jonathan J., Adcock, Ian M. and Punchard, N. 2011. Differential patterns of histone acetylation in inflammatory bowel diseases. Journal of Inflammation. 8 (1).
AuthorsTsaprouni, Loukia G., Ito, Kazuhiro, Powell, Jonathan J., Adcock, Ian M. and Punchard, N.
Abstract

Post-translational modifications of histones, particularly acetylation, are associated with the regulation of inflammatory gene expression. We used two animal models of inflammation of the bowel and biopsy samples from patients with Crohn's disease (CD) to study the expression of acetylated histones (H) 3 and 4 in inflamed mucosa. Acetylation of histone H4 was significantly elevated in the inflamed mucosa in the trinitrobenzene sulfonic acid model of colitis particularly on lysine residues (K) 8 and 12 in contrast to non-inflamed tissue. In addition, acetylated H4 was localised to inflamed tissue and to Peyer's patches (PP) in dextran sulfate sodium (DSS)-treated rat models. Within the PP, H3 acetylation was detected in the mantle zone whereas H4 acetylation was seen in both the periphery and the germinal centre. Finally, acetylation of H4 was significantly upregulated in inflamed biopsies and PP from patients with CD. Enhanced acetylation of H4K5 and K16 was seen in the PP. These results demonstrate that histone acetylation is associated with inflammation and may provide a novel therapeutic target for mucosal inflammation.

JournalJournal of Inflammation
Journal citation8 (1)
ISSN1476-9255
Year2011
PublisherBioMed Central
Publisher's version
License
CC BY
Web address (URL)http://dx.doi.org/10.1186/1476-9255-8-1
Publication dates
Print27 Jan 2011
Publication process dates
Deposited13 Mar 2015
Accepted27 Jan 2011
FunderGlaxoSmithKline
Copyright information© 2011 Tsaprouni et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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