The Role of Siglec-F as a Regulator of Alveolar Macrophage Function and Adaptation
Masters Thesis
Barker, C. J. 2019. The Role of Siglec-F as a Regulator of Alveolar Macrophage Function and Adaptation. Masters Thesis University of East London School of Health, Sport and Bioscience
Authors | Barker, C. J. |
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Type | Masters Thesis |
Abstract | 2019 dissertation for MRes. Alveolar macrophages are found in a truly unique microenvironment of the lung alveoli, where they are in close contact with the respiratory epithelium. This close contact with the epithelium is essential as it is how these highly inflammatory cells (cells that respond quickly to immune response as dysregulation of homeostasis exacerbates pathology) are regulated to prevent excessive inflammation, which otherwise would damage the lung, possibly leading to Asthma or COPD. Meaning that in the absence of pathology, the inflammatory response of alveolar macrophages are limited. Interaction with the lung occurs when macrophages bind to the epithelium through a specific receptor such as CD200R and possibly Siglec-F. Siglec-F is a lectin on the surface of macrophages that binds glycoconjugates containing sialic acid on the lung epithelium and on mucins, which is speculated to negatively regulate alveolar macrophages. Though the specific role of Siglec-F as a regulator of macrophage is not fully understood. |
Year | 2019 |
Publisher | University of East London |
File | License File Access Level Anyone |
Publication dates | |
Oct 2019 | |
Publication process dates | |
Deposited | 11 Dec 2020 |
https://repository.uel.ac.uk/item/8887q
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2019_MRes_Barker.pdf | |
License: CC BY-NC-ND 4.0 | |
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