Behavioural and neural markers of tactile sensory processing in infants at elevated likelihood of autism spectrum disorder and/or attention deficit hyperactivity disorder

Article


Piccardi, E. S., Begum Ali, J., Jones, E. J. H., Mason, L., Charman, T., Johnson, M. H., Gliga, T. and BASIS/STAARS Team 2021. Behavioural and neural markers of tactile sensory processing in infants at elevated likelihood of autism spectrum disorder and/or attention deficit hyperactivity disorder. Journal of Neurodevelopmental Disorders. 13 (Art. 1). https://doi.org/10.1186/s11689-020-09334-1
AuthorsPiccardi, E. S., Begum Ali, J., Jones, E. J. H., Mason, L., Charman, T., Johnson, M. H., Gliga, T. and BASIS/STAARS Team
Abstract

Backgrounds

Atypicalities in tactile processing are reported in autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) but it remains unknown if they precede and associate with the traits of these disorders emerging in childhood. We investigated behavioural and neural markers of tactile sensory processing in infants at elevated likelihood of ASD and/or ADHD compared to infants at typical likelihood of the disorders. Further, we assessed the specificity of associations between infant markers and later ASD or ADHD traits.

Methods

Ninety-one 10-month-old infants participated in the study (n = 44 infants at elevated likelihood of ASD; n = 20 infants at elevated likelihood of ADHD; n = 9 infants at elevated likelihood of ASD and ADHD; n = 18 infants at typical likelihood of the disorders). Behavioural and EEG responses to pairs of tactile stimuli were experimentally recorded and concurrent parental reports of tactile responsiveness were collected. ASD and ADHD traits were measured at 24 months through standardized assessment (ADOS-2) and parental report (ECBQ), respectively.

Results

There was no effect of infants’ likelihood status on behavioural markers of tactile sensory processing. Conversely, increased ASD likelihood associated with reduced neural repetition suppression to tactile input. Reduced neural repetition suppression at 10 months significantly predicted ASD (but not ADHD) traits at 24 months across the entire sample. Elevated tactile sensory seeking at 10 months moderated the relationship between early reduced neural repetition suppression and later ASD traits.

Conclusions

Reduced tactile neural repetition suppression is an early marker of later ASD traits in infants at elevated likelihood of ASD or ADHD, suggesting that a common pathway to later ASD traits exists despite different familial backgrounds. Elevated tactile sensory seeking may act as a protective factor, mitigating the relationship between early tactile neural repetition suppression and later ASD traits.

JournalJournal of Neurodevelopmental Disorders
Journal citation13 (Art. 1)
ISSN1866-1955
Year2021
PublisherBMC
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Anyone
Supplemental file
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Digital Object Identifier (DOI)https://doi.org/10.1186/s11689-020-09334-1
Publication dates
Print04 Jan 2021
Publication process dates
Accepted04 Nov 2020
Deposited05 Apr 2022
Copyright holder© 2021 The Authors
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