Closing the diagnostic gap: Liquid biopsy potential to transform ovarian cancer outcomes in sub-Saharan Africa

Article


Kokori, E., Olatunji, G., Ogieuhi, I. J., Muogbo, I., Isarinade, D., Ukoaka, B., Ajayi, I., Ezenwoba, C., Samuel, O., Nurudeen-Busari, H., Olawade, D. B. and Aderinto, N. 2024. Closing the diagnostic gap: Liquid biopsy potential to transform ovarian cancer outcomes in sub-Saharan Africa. Medicine. 105 (3), p. e37154. https://doi.org/10.1097/MD.0000000000037154
AuthorsKokori, E., Olatunji, G., Ogieuhi, I. J., Muogbo, I., Isarinade, D., Ukoaka, B., Ajayi, I., Ezenwoba, C., Samuel, O., Nurudeen-Busari, H., Olawade, D. B. and Aderinto, N.
Abstract

Ovarian cancer presents a significant health challenge in sub-Saharan Africa (SSA), where late-stage diagnosis contributes to high mortality rates. This diagnostic gap arises from limited resources, poor healthcare infrastructure, and a lack of awareness about the disease. However, a potential game-changer is emerging in the form of liquid biopsy (LB), a minimally invasive diagnostic method. This paper analyses the current diagnostic gap in ovarian cancer in SSA, highlighting the socio-economic, cultural, and infrastructural factors that hinder early diagnosis and treatment. It discusses the challenges and potential of LB in the context of SSA, emphasizing its cost-effectiveness and adaptability to resource-limited settings. The transformative potential of LB in SSA is promising, offering a safer, more accessible, and cost-effective approach to ovarian cancer diagnosis. This paper provides recommendations for future directions, emphasizing the need for research, infrastructure development, stakeholder engagement, and international collaboration. By recognizing the transformative potential of LB and addressing the diagnostic gap, we can pave the way for early detection, improved treatment, and better outcomes for ovarian cancer patients in SSA. This paper sheds light on a path toward better healthcare access and equity in the region.

JournalMedicine
Journal citation105 (3), p. e37154
ISSN0025-7974
1536-5964
Year2024
PublisherLippincott, Williams & Wilkins
Publisher's version
License
File Access Level
Anyone
Digital Object Identifier (DOI)https://doi.org/10.1097/MD.0000000000037154
Publication dates
Online02 Feb 2024
Publication process dates
Deposited23 Apr 2024
Copyright holder© 2024, The Authors
Permalink -

https://repository.uel.ac.uk/item/8x99x

Download files


Publisher's version
closing_the_diagnostic_gap__liquid_biopsy.67.pdf
License: CC BY 4.0
File access level: Anyone

  • 11
    total views
  • 6
    total downloads
  • 3
    views this month
  • 3
    downloads this month

Export as