Intragastric balloons for obesity: critical review of device design, efficacy, tolerability, and unmet clinical needs

Article


Ameen, S. and Merchant, H. A. 2023. Intragastric balloons for obesity: critical review of device design, efficacy, tolerability, and unmet clinical needs. Expert Review of Medical Devices. 21 (1-2), pp. 37-54. https://doi.org/10.1080/17434440.2023.2289691
AuthorsAmeen, S. and Merchant, H. A.
Abstract

Introduction
Sustaining a healthy weight is a challenge and obesity, with associated risk of co-morbidities, is a major public health concern. Bariatric surgery has shown a great promise for many where pharmacological and lifestyle interventions failed to work. However, challenges and limitations associated with bariatric surgery has pushed the demand for less invasive, reversible (anatomically) interventions, such as intragastric balloons (IGBs).

Areas covered
This review critically appraises IGBs used in the past, present, and those in clinical trials, discussing the device designs, limitations, placement and removal techniques, patient eligibility, efficacy, and safety issues.

Expert opinion
Several intragastric balloons were developed over the years that brought excitement to patients and healthcare professionals alike. Albeit good efficacy, there had been several safety issues reported with IGBs such as spontaneous deflation, intestinal occlusion, gut perforation, and mucosal ulcerations. This led to evolution of IGBs design; device material, filling mechanism, fluid type, inflation volume, and further innovations to ease ingestion and removal of device. There are some IGB devices under development aimed to swallow like a conventional pill and excrete naturally through defecation, however, how successful they will be in clinical practice in terms of their efficacy and tolerability remains to be seen in the future.

JournalExpert Review of Medical Devices
Journal citation21 (1-2), pp. 37-54
ISSN1743-4440
1745-2422
Year2023
PublisherTaylor & Francis
Publisher's version
License
File Access Level
Anyone
Digital Object Identifier (DOI)https://doi.org/10.1080/17434440.2023.2289691
Publication dates
Online04 Dec 2023
Publication process dates
Deposited23 Apr 2024
Copyright holder© 2023, The Authors
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