Understanding the mechanisms underlying cognitive control in psychosis

Article


Maitra, R., Lemmers-Jansen, I. L. J., Vooren, M., Vanes, L., Szentgyorgyi, T., Crisp, C., Mouchlianitis, E. and Shergill, S. S. 2024. Understanding the mechanisms underlying cognitive control in psychosis. Psychological Medicine. In Press. https://doi.org/10.1017/S0033291724001119
AuthorsMaitra, R., Lemmers-Jansen, I. L. J., Vooren, M., Vanes, L., Szentgyorgyi, T., Crisp, C., Mouchlianitis, E. and Shergill, S. S.
Abstract

Background
Cognitive control (CC) involves a top–down mechanism to flexibly respond to complex stimuli and is impaired in schizophrenia.

Methods
This study investigated the impact of increasing complexity of CC processing in 140 subjects with psychosis and 39 healthy adults, with assessments of behavioral performance, neural regions of interest and symptom severity.

Results
The lowest level of CC (Stroop task) was impaired in all patients; the intermediate level of CC (Faces task) with explicit emotional information was most impaired in patients with first episode psychosis. Patients showed activation of distinct neural CC and reward networks, but iterative learning based on the higher-order of CC during the trust game, was most impaired in chronic schizophrenia. Subjects with first episode psychosis, and patients with lower symptom load, demonstrate flexibility of the CC network to facilitate learning, which appeared compromised in the more chronic stages of schizophrenia.

Conclusion
These data suggest optimal windows for opportunities to introduce therapeutic interventions to improve CC.

JournalPsychological Medicine
Journal citationIn Press
ISSN0033-2917
1469-8978
Year2024
PublisherCambridge University Press
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Anyone
Supplemental file
License
File Access Level
Anyone
Digital Object Identifier (DOI)https://doi.org/10.1017/S0033291724001119
Publication dates
Online23 May 2024
Publication process dates
Accepted16 Apr 2024
Deposited16 Jul 2024
Copyright holder© 2024, The Author(s)
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License: CC BY-NC-ND 4.0
File access level: Anyone

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