Dr Tony Raynham

NameDr Tony Raynham
Job titleSenior Lecturer
Email addresstraynham@uel.ac.uk
Research instituteHealth, Sport & Bioscience

Research outputs

Molecular basis of USP7 inhibition by selective small-molecule inhibitors

Turnbull, Andrew P., Ioannidis, Stephanos, Krajewski, Wojciech W., Pinto-Fernandez, Adan, Heride, Claire, Martin, Agnes C. L., Tonkin, Louise M., Townsend, Elizabeth C., Buker, Shane M., Lancia, David R., Caravella, Justin A., Toms, Angela V., Charlton, Thomas M., Lahdenranta, Johanna, Wilker, Erik, Follows, Bruce C., Evans, Nicola J., Stead, Lucy, Alli, Cristina, Zarayskiy, Vladislav V., Talbot, Adam C., Buckmelter, Alexandre J., Wang, Minghua, McKinnon, Crystal L., Saab, Fabienne, McGouran, Joanna F., Century, Hannah, Gersch, Malte, Pittman, Marc S., Marshall, C. Gary, Raynham, T., Simcox, Mary, Stewart, Lorna M. D., McLoughlin, Sheila B., Escobedo, Jaime A., Bair, Kenneth W., Dinsmore, Christopher J., Hammonds, Tim R., Kim, Sunkyu, Urbé, Sylvie, Clague, Michael J., Kessler, Benedikt M. and Komander, David 2017. Molecular basis of USP7 inhibition by selective small-molecule inhibitors. Nature. 550 (7677), pp. 481-486. https://doi.org/10.1038/nature24451

Investigation of the Role of Protein Kinase D in Human Rhinovirus Replication

Guedán, Anabel, Swieboda, Dawid, Charles, Mark, Toussaint, Marie, Johnston, Sebastian L., Asfor, Amin, Panjwani, Anusha, Tuthill, Tobias J., Danahay, Henry, Raynham, T., Mousnier, Aurelie, Solari, Roberto and Pfeiffer, Julie K. 2017. Investigation of the Role of Protein Kinase D in Human Rhinovirus Replication. Journal of Virology. 91 (9), pp. e00217-17. https://doi.org/10.1128/JVI.00217-17

Discovery of potent inhibitors of the lysophospholipase autotaxin

Shah, Pritom, Cheasty, Anne, Foxton, Caroline, Raynham, T., Farooq, Muddasar, Gutierrez, Irene Farre, Lejeune, Aurore, Pritchard, Michelle, Turnbull, Andrew, Pang, Leon, Owen, Paul, Boyd, Susan, Stowell, Alexandra, Jordan, Allan, Hamilton, Niall M., Hitchin, James R., Stockley, Martin, MacDonald, Ellen, Quesada, Mar Jimenez, Trivier, Elisabeth, Skeete, Jana, Ovaa, Huib, Moolenaar, Wouter H. and Ryder, Hamish 2016. Discovery of potent inhibitors of the lysophospholipase autotaxin. Bioorganic & Medicinal Chemistry Letters. 26 (22), pp. 5403-5410. https://doi.org/10.1016/j.bmcl.2016.10.036

Morpholylureas are a new class of potent and selective inhibitors of the type 5 17-β-hydroxysteroid dehydrogenase (AKR1C3)

Flanagan, Jack U., Atwell, Graham J., Heinrich, Daniel M., Brooke, Darby G., Silva, Shevan, Rigoreau, Laurent J.M., Trivier, Elisabeth, Turnbull, Andrew P., Raynham, T., Jamieson, Stephen M.F. and Denny, William A. 2014. Morpholylureas are a new class of potent and selective inhibitors of the type 5 17-β-hydroxysteroid dehydrogenase (AKR1C3). Bioorganic & Medicinal Chemistry. 22 (3), pp. 967-977. https://doi.org/10.1016/j.bmc.2013.12.050

Protein kinase D2 regulates migration and invasion of U87MG glioblastoma cells in vitro

Bernhart, Eva, Damm, Sabine, Wintersperger, Andrea, DeVaney, Trevor, Zimmer, Andreas, Raynham, T., Ireson, Christopher and Sattler, Wolfgang 2013. Protein kinase D2 regulates migration and invasion of U87MG glioblastoma cells in vitro. Experimental Cell Research. 319 (13), pp. 2037-2048. https://doi.org/10.1016/j.yexcr.2013.03.029
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