Hedgehog Signalling in the Embryonic Mouse Thymus

Article


Barbarulo, Alessandro, Lau, Ching-In, Mengrelis, Konstantinos, Ross, Susan, Solanki, Anisha, Saldaña, J. and Crompton, Tessa 2016. Hedgehog Signalling in the Embryonic Mouse Thymus. Journal of Developmental Biology. 4 (3).
AuthorsBarbarulo, Alessandro, Lau, Ching-In, Mengrelis, Konstantinos, Ross, Susan, Solanki, Anisha, Saldaña, J. and Crompton, Tessa
Abstract

T cells develop in the thymus, which provides an essential environment for T cell fate
specification, and for the differentiation of multipotent progenitor cells into major histocompatibility
complex (MHC)-restricted, non-autoreactive T cells. Here we review the role of the Hedgehog
signalling pathway in T cell development, thymic epithelial cell (TEC) development, and
thymocyte–TEC cross-talk in the embryonic mouse thymus during the last week of gestation.

Keywordsthymus; Hedgehog; Shh; Ihh; T cell development; thymic epithelial cell (TEC); Gli3; Gli2; Gli1
JournalJournal of Developmental Biology
Journal citation4 (3)
ISSN2221-3759
Year2016
PublisherMultidisciplinary Digital Publishing Institute (MDPI)
Publisher's version
License
CC BY
Digital Object Identifier (DOI)doi:10.3390/jdb4030022
Publication dates
Print16 Jul 2016
Publication process dates
Deposited31 Jan 2017
Accepted14 Jul 2016
FunderMedical Research Council (MRC)
Biotechnology and Biological Sciences Research Council (BBSRC)
Wellcome Trust
National Institute for Health Research Biomedical Research Centre
Great Ormond Street Hospital for Children NHS Foundation Trust
Istituto Pasteur/Cenci Bolognetti Foundation
Great Ormond Street Hospital Children’s Charity
Medical Research Council
Biotechnology and Biological Sciences Research Council
Wellcome Trust
National Institute for Health Research
Great Ormond Street Hospital for Children
Istituto Pasteur/Cenci Bolognetti
Great Ormond Street Hospital Charity
Copyright information© 2016 the authors. This article is an open access article published by MDPI, Basel, Switzerland.
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