Hedgehog Signalling in the Embryonic Mouse Thymus

Article

Barbarulo, A., Lau, C-I., Mengrelis, K., Ross, S., Solanki, A., Saldaña, J. and Crompton, T. 2016. Hedgehog Signalling in the Embryonic Mouse Thymus. Journal of Developmental Biology. 4 (3), p. 22. https://doi.org/10.3390/jdb4030022
AuthorsBarbarulo, A., Lau, C-I., Mengrelis, K., Ross, S., Solanki, A., Saldaña, J. and Crompton, T.
Abstract

T cells develop in the thymus, which provides an essential environment for T cell fate specification, and for the differentiation of multipotent progenitor cells into major histocompatibility complex (MHC)-restricted, non-autoreactive T cells. Here we review the role of the Hedgehog signalling pathway in T cell development, thymic epithelial cell (TEC) development, and thymocyte–TEC cross-talk in the embryonic mouse thymus during the last week of gestation.

Keywordsthymus; Hedgehog; Shh; Ihh; T cell development; thymic epithelial cell (TEC); Gli3; Gli2; Gli1
JournalJournal of Developmental Biology
Journal citation4 (3), p. 22
ISSN2221-3759
Year2016
PublisherMDPI
Publisher's version
License
File Access Level
Anyone
Digital Object Identifier (DOI)https://doi.org/10.3390/jdb4030022
Publication dates
Print16 Jul 2016
Publication process dates
Deposited31 Jan 2017
Accepted14 Jul 2016
FunderMedical Research Council (MRC)
Biotechnology and Biological Sciences Research Council (BBSRC)
Wellcome Trust
National Institute for Health Research Biomedical Research Centre
Great Ormond Street Hospital for Children NHS Foundation Trust
Istituto Pasteur/Cenci Bolognetti Foundation
Great Ormond Street Hospital Children’s Charity
Medical Research Council
Biotechnology and Biological Sciences Research Council
Wellcome Trust
National Institute for Health Research
Great Ormond Street Hospital for Children
Istituto Pasteur/Cenci Bolognetti
Great Ormond Street Hospital Charity
Copyright holder© 2016, The Authors
Permalink -

https://repository.uel.ac.uk/item/8502q

Log in to edit

Download files

Publisher's version
jdb-04-00022 - J. Saldana.pdf
License: CC BY 4.0
File access level: Anyone

  • 119
    total views
  • 207
    total downloads
  • 1
    views this month
  • 1
    downloads this month

Export as

Related outputs

Foxa1 and Foxa2 in thymic epithelial cells (TEC) regulate medullary TEC and regulatory T-cell maturation
Lau, Ching-In, Yánez, Diana C., Solanki, Anisha, Papaioannou, Eleftheria, Saldaña, J. and Crompton, Tessa 2018. Foxa1 and Foxa2 in thymic epithelial cells (TEC) regulate medullary TEC and regulatory T-cell maturation. Journal of Autoimmunity. 93, pp. 131-138. https://doi.org/10.1016/j.jaut.2018.07.009
Gli3 in fetal thymic epithelial cells promotes thymocyte positive selection and differentiation by repression of Shh
Solanki, Anisha, Yanez, Diana C., Ross, Susan, Lau, Ching-In, Papaioannou, Eleftheria, Li, Jiawei, Saldaña, J. and Crompton, Tessa 2018. Gli3 in fetal thymic epithelial cells promotes thymocyte positive selection and differentiation by repression of Shh. Development. 145 (3), p. dev146910. https://doi.org/10.1242/dev.146910
The kinesin motor protein Kif7 is required for T-cell development and normal MHC expression on thymic epithelial cells (TEC) in the thymus
Lau, Ching-In, Barbarulo, Alessandro, Solanki, Anisha, Saldaña, J. and Crompton, Tessa 2017. The kinesin motor protein Kif7 is required for T-cell development and normal MHC expression on thymic epithelial cells (TEC) in the thymus. Oncotarget. 8 (15), pp. 24163-24176. https://doi.org/10.18632/oncotarget.15241
A genome wide transcriptional model of the complex response to pre-TCR signalling during thymocyte differentiation
Sahni, Hemant, Susan, Ross, Barbarulo, Alessandro, Solanki, Anisha, Lau, Ching-In, Furmanski, Anna, Saldaña, J., Ono, Masahiro, Hubank, Mike, Barenco, Martino and Crompton, Tessa 2015. A genome wide transcriptional model of the complex response to pre-TCR signalling during thymocyte differentiation. Oncotarget. 6 (30), pp. 28646-28660. https://doi.org/10.18632/oncotarget.5796
The transcription factor Gli3 promotes B cell development in fetal liver through repression of Shh
Solanki, Anisha, Lau, Ching-In, Saldaña, J., Ross, Susan and Crompton, Tessa 2017. The transcription factor Gli3 promotes B cell development in fetal liver through repression of Shh. The Journal of Experimental Medicine. 214 (7), pp. 2041 -2058. https://doi.org/10.1084/jem.20160852
Sonic Hedgehog regulates thymic epithelial cell differentiation
Saldaña, J., Solanki, Anisha, Lau, Ching-In, Sahni, Hemant, Ross, Susan, Furmanski, Anna L., Ono, Masahiro, Holländer, Georg and Crompton, Tessa 2016. Sonic Hedgehog regulates thymic epithelial cell differentiation. Journal of Autoimmunity. 68 (April), pp. 86-97. https://doi.org/10.1016/j.jaut.2015.12.004