Fc-fusion mimetics

Article


Khalili, H., Khaw, P. T. and Brocchini, S. 2016. Fc-fusion mimetics. Biomaterials Science. 4 (6), pp. 943-947.
AuthorsKhalili, H., Khaw, P. T. and Brocchini, S.
Abstract

The Fc-fusion mimetic RpR 2 was prepared by disulfide bridging conjugation using a PEG in the place of the Fc. RpR 2 displayed higher affinity for VEGF than aflibercept caused primarily by a slower dissociation rate, which can prolong a drug at its site of action. RpRs have considerable potential for development as stable, organ specific therapeutics.

JournalBiomaterials Science
Journal citation4 (6), pp. 943-947
ISSN2047-4849
2047-4830
Year2016
PublisherRoyal Society of Chemistry
Accepted author manuscript
Digital Object Identifier (DOI)doi:10.1039/C6BM00077K
Publication dates
Print29 Apr 2016
Publication process dates
Deposited20 Oct 2016
Accepted08 Apr 2016
FunderNational Institute of Health Research Biomedical Research Centre
Moorfields Special Trustees
Helen Hamlyn Trust
Medical Research Council
Fight For Sight
Freemasons Grand Charity
Engineering & Physical Sciences Research Council Centre for Innovative Manufacturing in Emergent Macromolecular Therapies
Permalink -

https://repository.uel.ac.uk/item/85141

  • 5
    total views
  • 32
    total downloads
  • 1
    views this month
  • 10
    downloads this month

Related outputs

Comparative thermodynamic analysis in solution of a next generation antibody mimetic to VEGF
Khalili, H., Brocchini, Steve, Khaw, Peng Tee and Filippov, Sergey K. 2018. Comparative thermodynamic analysis in solution of a next generation antibody mimetic to VEGF. RSC Advances. 8 (62), pp. 35787-35793.
Storage Stability Studies of Anti-VEGF FpF Antibody Mimetics
Khalili, H., Brocchini, Steve, Khaw, Peng Tee and Filippov, Sergey 2016. Storage Stability Studies of Anti-VEGF FpF Antibody Mimetics. 2016 AAPS Annual Meeting and Exposition. Denver, Co, USA 13 - 17 Nov 2016 American Association of Pharmaceutical Scientists.
An anti-TNF--α antibody mimetic to treat ocular inflammation
Khalili, H., Lee, Richard W., Khaw, Peng Tee, Brocchini, Steve, Dick, Andrew D. and Copland, David A. 2016. An anti-TNF--α antibody mimetic to treat ocular inflammation. Scientific Reports. 6 (36905).
Storage stability of bevacizumab in polycarbonate and polypropylene syringes
Khalili, H., Sharma, Garima, Froome, Andrew, Khaw, Peng Tee and Brocchini, Steve 2015. Storage stability of bevacizumab in polycarbonate and polypropylene syringes. Eye. 29 (6), pp. 820-827.