Prospective memory deficits in illicit polydrug users are associated with the average long-term typical dose of ecstasy typically consumed in a single session.

Article


Gallagher, Denis T., Hadjiefthyvoulou, F., Fisk, John E., Montgomery, Catharine, Robinson, Sarita J. and Judge, Jeannie 2014. Prospective memory deficits in illicit polydrug users are associated with the average long-term typical dose of ecstasy typically consumed in a single session. Neuropsychology. 28 (1), pp. 43-54.
AuthorsGallagher, Denis T., Hadjiefthyvoulou, F., Fisk, John E., Montgomery, Catharine, Robinson, Sarita J. and Judge, Jeannie
Abstract

Rationale: Neuroimaging evidence suggests that ecstasy-related reductions in SERT densities relate more closely to the number of tablets typically consumed per session rather than estimated total lifetime use. To better understand the basis of drug related deficits in prospective memory (p.m.) we explored the association between p.m. and average long-term typical dose and long-term frequency of use. Method: Study 1: Sixty-five ecstasy/polydrug users and 85 nonecstasy users completed an event-based, a short-term and a long-term time-based p.m. task. Study 2: Study 1 data were merged with outcomes on the same p.m. measures from a previous study creating a combined sample of 103 ecstasy/polydrug users, 38 cannabis-only users, and 65 nonusers of illicit drugs. Results: Study 1: Ecstasy/polydrug users had significant impairments on all p.m. outcomes compared with nonecstasy users. Study 2: Ecstasy/polydrug users were impaired in event-based p.m. compared with both other groups and in long-term time-based p.m. compared with nonillicit drug users. Both drug using groups did worse on the short-term time-based p.m. task compared with nonusers. Higher long-term average typical dose of ecstasy was associated with poorer performance on the event and short-term time-based p.m. tasks and accounted for unique variance in the two p.m. measures over and above the variance associated with cannabis and cocaine use. Conclusions: The typical ecstasy dose consumed in a single session is an important predictor of p.m. impairments with higher doses reflecting increasing tolerance giving rise to greater p.m. impairment.

JournalNeuropsychology
Journal citation28 (1), pp. 43-54
ISSN0894-4105
1931-1559
Year2014
PublisherAmerican Psychological Association
Accepted author manuscript
Digital Object Identifier (DOI)doi:10.1037/neu0000004
Web address (URL)https://doi.org/10.1037/neu0000004
Publication dates
PrintJan 2014
Publication process dates
Deposited07 Nov 2018
Copyright information© American Psychological Association, 2014. This paper is not the copy of record and may not exactly replicate the authoritative document published in the APA journal. Please do not copy or cite without author's permission. The final article is available, upon publication, at: https://doi.org/10.1037/neu0000004.
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