The Role of Neurotransmitters in Protection against Amyloid-β Toxicity by KiSS-1 Overexpression in SH-SY5Y Neurons
Article
Chilumuri, A. and Milton, Nathaniel G. N. 2013. The Role of Neurotransmitters in Protection against Amyloid-β Toxicity by KiSS-1 Overexpression in SH-SY5Y Neurons. ISRN Neuroscience. 2013 (253210), pp. 1-14. https://doi.org/10.1155/2013/253210
Authors | Chilumuri, A. and Milton, Nathaniel G. N. |
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Abstract | Recent studies have suggested that the kisspeptin (KP) and kissorphin (KSO) peptides have neuroprotective actions against the Alzheimer’s amyloid-β (Aβ) peptide. Overexpression of the human KiSS-1 gene that codes for KP and KSO peptides in SH-SY5Y neurons has also been shown to inhibit Aβ neurotoxicity. The in vivo actions of KP include activation of neuroendocrine and neurotransmitter systems. The present study used antagonists of KP, neuropeptide FF (NPFF), opioids, oxytocin, estrogen, adrenergic, cholinergic, dopaminergic, serotonergic, and γ-aminobutyric acid (GABA) receptors plus inhibitors of catalase, cyclooxygenase, nitric oxide synthase, and the mitogen activated protein kinase cascade to characterize the KiSS-1 gene overexpression neuroprotection against Aβ cell model. The results showed that KiSS-1 overexpression is neuroprotective against Aβ and the action appears to involve the KP or KSO peptide products of KiSS-1 processing. The mechanism of neuroprotection does not involve the activation of the KP or NPFF receptors. Opioids play a role in the toxicity of Aβ in the KiSS-1 overexpression system and opioid antagonists naloxone or naltrexone inhibited Aβ toxicity. The mechanism of KiSS-1 overexpression induced protection against Aβ appears to have an oxytocin plus a cyclooxygenase dependent component, with the oxytocin antagonist atosiban and the cyclooxygenase inhibitor SC-560 both enhancing the toxicity of Aβ. |
Journal | ISRN Neuroscience |
Journal citation | 2013 (253210), pp. 1-14 |
ISSN | 2314-4661 |
2314-4661 | |
Year | 2013 |
Publisher | Hindawi Publishing Corporation |
Publisher's version | License CC BY |
Digital Object Identifier (DOI) | https://doi.org/10.1155/2013/253210 |
Publication dates | |
17 Jul 2013 | |
Publication process dates | |
Deposited | 17 Mar 2017 |
Accepted | 19 Jun 2013 |
Funder | University of Roehampton |
University of Westminister | |
University of Roehampton | |
University of Westminister | |
Copyright information | © 2013 The Authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
https://repository.uel.ac.uk/item/85w9q
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