Inhibitory Studies of Tamarindus indica Seed Extract and Fractions on Hematological Activities of Bitis arietans Venom

Article


Baggi, B. I., Yusuf, P.O. and Alloh, F. 2020. Inhibitory Studies of Tamarindus indica Seed Extract and Fractions on Hematological Activities of Bitis arietans Venom. Journal of Advances in Biology and Biotechnology. 23 (4), pp. 48-57.
AuthorsBaggi, B. I., Yusuf, P.O. and Alloh, F.
Abstract

Envenomation is a serious public health and occupational hazard in tropical and subtropical countries. Antivenom serum treatment has been related to extreme hypersensitivity, high cost, and inaccessibility. Consequently, therapeutic plants have been investigated to give an alternative treatment. The aim of this study was to evaluate the ability of the methanolic extract and fractions of Tamarindus indica seeds to neutralize the hemolytic, anticoagulant and hemorrhagic activities of Bitis arietans venom. The powdered form of Tamarindus indica seed was extracted using methanol. The methanol extract was further fractionated using butanol solvent. The aqueous fraction of the methanolic extract inhibited hemolysis caused by crude venom by 95.5%, while methanolic extract significantly reduced the anticoagulant time of crude venom to 10.2%. The in vivo hemorrhagic activity of the crude venom of Bitis arietans was neutralized by both the crude methanolic extract and the subsequent two fractions of Tamarindus indica seed. However, the crude methanolic extract was found to be the most active by reducing the hemorrhage diameter caused by crude venom to 39%. The findings of this present research work demonstrated a very good antivenom properties of the seeds of Tamarindus indica, which suggests that it could be a potential source of effective, and safe compounds with inhibitory activities against Bitis arietans envenomation.

KeywordsAntivenom; Bitis arietans; Tamarindus indica; hemolytic; anticoagulant; hemorrhagic
JournalJournal of Advances in Biology and Biotechnology
Journal citation23 (4), pp. 48-57
ISSN2394-1081
Year2020
PublisherSCIENCEDOMAIN International
Publisher's version
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File Access Level
Anyone
Digital Object Identifier (DOI)doi:10.9734/jabb/2020/v23i430152
Web address (URL)https://doi.org/10.9734/jabb/2020/v23i430152
Publication dates
Print13 Jul 2020
Publication process dates
Accepted01 Jul 2020
Deposited16 Jul 2020
Copyright holder© 2020 The Authors
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