Synthesis and Characterization of Silver-Coated Polymeric Scaffolds for Bone Tissue Engineering: Antibacterial and In Vitro Evaluation of Cytotoxicity and Biocompatibility

Article


Khan, M. U. A., Abd Razak, S. I., Mehboob, H., Abdul Kadir, M. R., Anand, T. J. S., Inam, F., Shah, S. A., Abdel-Haliem, M. E. F. and Amin, R. 2021. Synthesis and Characterization of Silver-Coated Polymeric Scaffolds for Bone Tissue Engineering: Antibacterial and In Vitro Evaluation of Cytotoxicity and Biocompatibility. ACS Omega. https://doi.org/10.1021/acsomega.0c05596
AuthorsKhan, M. U. A., Abd Razak, S. I., Mehboob, H., Abdul Kadir, M. R., Anand, T. J. S., Inam, F., Shah, S. A., Abdel-Haliem, M. E. F. and Amin, R.
Abstract

In bone tissue engineering, multifunctional composite materials are very challenging. Bone tissue engineering is an innovative technique to develop biocompatible scaffolds with suitable orthopedic applications with enhanced antibacterial and mechanical properties. This research introduces a polymeric nanocomposite scaffold based on arabinoxylan-co-acrylic acid, nano-hydroxyapatite (nHAp), nano-aluminum oxide (nAl₂O₃), and graphene oxide (GO) by free-radical polymerization for the development of porous scaffolds using the freeze-drying technique. These polymeric nanocomposite scaffolds were coated with silver (Ag) nanoparticles to improve antibacterial activities. Together, nHAp, nAl₂O₃, and GO enhance the multifunctional properties of materials, which regulate their physicochemical and biomechanical properties. Results revealed that the Ag-coated polymeric nanocomposite scaffolds had excellent antibacterial properties and better microstructural properties. Regulated morphological properties and maximal antibacterial inhibition zones were found in the porous scaffolds with the increasing amount of GO. Moreover, the nanosystem and the polymeric matrix have improved the compressive strength (18.89 MPa) and Young’s modulus (198.61 MPa) of scaffolds upon increasing the amount of GO. The biological activities of the scaffolds were investigated against the mouse preosteoblast cell lines (MC3T3-E1) and increasing the quantities of GO helps cell adherence and proliferation. Therefore, our findings showed that these silver-coated polymeric nanocomposite scaffolds have the potential for engineering bone tissue.

JournalACS Omega
ISSN2470-1343
Year2021
PublisherAmerican Chemical Society
Publisher's version
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Anyone
Digital Object Identifier (DOI)https://doi.org/10.1021/acsomega.0c05596
Publication dates
Online02 Feb 2021
Publication process dates
Accepted14 Jan 2021
Deposited08 Feb 2021
FunderUniversiti Teknologi Malaysia
Prince Sultan University
Copyright holder© 2021 The Authors
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