The Interaction of Diet and Mitochondrial Dysfunction in Aging and Cognition

Article

Kaliszewska, A., Allison, J., Martini, M. and Arias, N. 2021. The Interaction of Diet and Mitochondrial Dysfunction in Aging and Cognition. International Journal of Molecular Sciences. 22 (Art. 3574). https://doi.org/10.3390/ijms22073574
AuthorsKaliszewska, A., Allison, J., Martini, M. and Arias, N.
Abstract

Aging is inevitable and it is one of the major contributors to cognitive decline. However, the mechanisms underlying age-related cognitive decline are still the object of extensive research. At the biological level, it is unknown how the aging brain is subjected to progressive oxidative stress and neuroinflammation which determine, among others, mitochondrial dysfunction. The link between mitochondrial dysfunction and cognitive impairment is becoming ever more clear by the presence of significant neurological disturbances in human mitochondrial diseases. Possibly, the most important lifestyle factor determining mitochondrial functioning is nutrition. Therefore, with the present work, we review the latest findings disclosing a link between nutrition, mitochondrial functioning and cognition, and pave new ways to counteract cognitive decline in late adulthood through diet.

JournalInternational Journal of Molecular Sciences
Journal citation22 (Art. 3574)
ISSN1661-6596
Year2021
PublisherMDPI
Publisher's version
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File Access Level
Anyone
Digital Object Identifier (DOI)https://doi.org/10.3390/ijms22073574
Publication dates
Online30 Mar 2021
Publication process dates
Accepted25 Mar 2021
Deposited08 Apr 2021
FunderUK Dementia Research Institute and the Ministry of Science, Innovation and Universities
Ministry of Economy and Business
Copyright holder© 2021 The Authors
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