The effect of isometric exercise training on arterial stiffness: A randomized crossover controlled study

Article


Edwards, J., Jalaludeen, J., Beqiri, A., Wiles, J., Sharma, R. and O'Driscoll, J. 2023. The effect of isometric exercise training on arterial stiffness: A randomized crossover controlled study. Physiological Reports. 11 (10), p. e15690. https://doi.org/10.14814/phy2.15690
AuthorsEdwards, J., Jalaludeen, J., Beqiri, A., Wiles, J., Sharma, R. and O'Driscoll, J.
Abstract

Isometric exercise training (IET) is an effective intervention for the management of resting blood pressure (BP). However, the effects of IET on arterial stiffness remain largely unknown. Eighteen unmedicated physically inactive participants were recruited. Participants were randomly allocated in a cross-over design to 4 weeks of home-based wall squat IET and control period, separated by a 3-week washout period. Continuous beat-to-beat hemodynamics, including early and late systolic (sBP 1 and sBP 2, respectively) and diastolic blood pressure (dBP) were recorded for a period of 5 min and waveforms were extracted and analyzed to acquire the augmentation index (AIx) as a measure of arterial stiffness. sBP 1 (-7.7 ± 12.8 mmHg, p = 0.024), sBP 2 (-5.9 ± 9.9 mmHg, p = 0.042) and dBP (-4.4 ± 7.2 mmHg, p = 0.037) all significantly decreased following IET compared to the control period. Importantly, there was a significant reduction in AIx following IET (-6.6 ± 14.5%, p = 0.02) compared to the control period. There were also adjacent significant reductions in total peripheral resistance (-140.7 ± 65.8 dynes·cm-5, p = 0.042) and pulse pressure (-3.8 ± 4.2, p = 0.003) compared to the control period. This study demonstrates an improvement in arterial stiffness following a short-term IET intervention. These findings have important clinical implications regarding cardiovascular risk. Mechanistically, these results suggest that reductions in resting BP following IET are induced via favorable vascular adaptations, although the intricate details of such adaptations are not yet clear.

JournalPhysiological Reports
Journal citation11 (10), p. e15690
ISSN2051-817X
Year2023
PublisherWiley Open Access for The Physiological Society and the American Physiological Society
Accepted author manuscript
File Access Level
Repository staff only
Publisher's version
License
File Access Level
Anyone
Digital Object Identifier (DOI)https://doi.org/10.14814/phy2.15690
Publication dates
Online19 May 2023
Publication process dates
Accepted03 May 2023
Deposited15 Jul 2024
Copyright holder© 2023, The Author(s)
Permalink -

https://repository.uel.ac.uk/item/8xy62

  • 20
    total views
  • 10
    total downloads
  • 6
    views this month
  • 1
    downloads this month

Export as

Related outputs

International Criteria for Reporting Study Quality for Sudden Cardiac Arrest/Death Tool
Edwards, J., Compton, C., Chatrath, N., Petek, B. J., Baggish, A., Borjesson, M., Chung, E., Corrado, D., Drezner, J. A., Gati, S., Gray, B., Kim, J., La Gerche, A., Malhotra, A., Marijon, E., Papadakis, M., Pelliccia, A., Phelan, D., Semsarian, C., Sharma, S., Sharma, R., O'Driscoll, J. M. and Harmon, K. G. 2024. International Criteria for Reporting Study Quality for Sudden Cardiac Arrest/Death Tool. Journal of the American Heart Association. 13 (11), p. e033723. https://doi.org/10.1161/JAHA.123.033723
Isometric Exercise Training and Arterial Hypertension: An Updated Review
Edwards, J. J., Coleman, D. A., Ritti-Dias, R. M., Farah, B. Q., Stensel, D, J., Lucas, S. J. E., Millar, P. J., Gordon, B. D. H., Cornelissen, V., Smart, N. A., Carlson, D. J., McGowan, C., Swaine, I., Pescatello, L. S., Howden, R., Bruce-Low, S., Farmer, C. K., Leeson, P., Sharma, R. and O'Driscoll, J. M. 2024. Isometric Exercise Training and Arterial Hypertension: An Updated Review. Sports Medicine. In Press. https://doi.org/10.1007/s40279-024-02036-x
Differences in Biomechanical Determinants of ACL Injury Risk in Change of Direction Tasks Between Males and Females: A Systematic Review and Meta-Analysis
Donelon, T. A., Edwards, J., Brown, M., Jones, P. A., O'Driscoll, J. and Dos'Santos, T. 2024. Differences in Biomechanical Determinants of ACL Injury Risk in Change of Direction Tasks Between Males and Females: A Systematic Review and Meta-Analysis. Sports Medicine - Open. 10 (1), pp. 1-22. https://doi.org/10.1186/s40798-024-00701-z
The effects of high intensity interval training on quality of life: a systematic review and meta-analysis.
Griffiths, M., Edwards, J., Mcnamara, J., Galbraith, A., Bruce-Low, S. and O’Driscoll, J. M. 2024. The effects of high intensity interval training on quality of life: a systematic review and meta-analysis. Journal of Public Health. In Press. https://doi.org/10.1007/s10389-024-02192-4
Exercise training and resting blood pressure: a large-scale pairwise and network meta-analysis of randomised controlled trials
Edwards, J. J., Deenmamode, A. H. P., Griffiths, M., Arnold, O., Cooper, N. J., Wiles, J. D. and O'Driscoll, J. M. 2023. Exercise training and resting blood pressure: a large-scale pairwise and network meta-analysis of randomised controlled trials. British Journal of Sports Medicine. 57, pp. 1317-1326. https://doi.org/10.1136/bjsports-2022-106503
High-Intensity Interval Training and Cardiometabolic Health in the General Population: A Systematic Review and Meta-Analysis of Randomised Controlled Trials
Edwards, J., Griffiths, M., Deenmamode, A. and O'Driscoll, J. 2023. High-Intensity Interval Training and Cardiometabolic Health in the General Population: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. Sports Medicine. 53, pp. 1753-1763. https://doi.org/10.1007/s40279-023-01863-8
The value of cardiopulmonary exercise testing and stress echocardiography in the prediction of all-cause mortality in adults with end stage renal disease
O'Driscoll, J, Edwards, J., Greenbough, E., Smith, E, May, M., Gupta, S., Marciniak, A. and Sharma, R. 2023. The value of cardiopulmonary exercise testing and stress echocardiography in the prediction of all-cause mortality in adults with end stage renal disease. European Journal Of Sport Science. 23 (17), pp. 1800-1809. https://doi.org/10.1080/17461391.2023.2184727
Exercise Mode in Heart Failure: A Systematic Review and Meta-Analysis
Edwards, J., Shanmugam, N., Wray, R., Jouhra, F., Mancio, J., Wiles, J., Marciniak, A., Sharma, R. and O'Driscoll, J. 2023. Exercise Mode in Heart Failure: A Systematic Review and Meta-Analysis. Sports Medicine - Open. 9 (Art. 3). https://doi.org/10.1186/s40798-022-00549-1
The Acute Impact of Endurance Exercise on Right Ventricular Structure and Function
Ramcharan, T., Edwards, J., O'Driscoll, J. and Papadakis, M. 2023. The Acute Impact of Endurance Exercise on Right Ventricular Structure and Function. Cardiology Clinics. 41 (1), pp. 25-34. https://doi.org/10.1016/j.ccl.2022.08.004
Myocardial performance index as a measure of global left ventricular function improves following isometric exercise training in hypertensive patients
Edwards, J. J., Jalaludeen, N., Taylor, K. A., Wiles, J. D. and O'Driscoll, J. M. 2023. Myocardial performance index as a measure of global left ventricular function improves following isometric exercise training in hypertensive patients. Hypertension Research. 46, pp. 468-474. https://doi.org/10.1038/s41440-022-01019-7
Exercise Training in Heart failure with Preserved and Reduced Ejection Fraction: A Systematic Review and Meta-Analysis
Edwards, J. and O'Driscoll, J. 2022. Exercise Training in Heart failure with Preserved and Reduced Ejection Fraction: A Systematic Review and Meta-Analysis. Sports Medicine - Open. 8 (Art. 76). https://doi.org/10.1186/s40798-022-00464-5
Both Sides of a Coin: Having Open Heart Surgery While Researching in Cardiology
Edwards, J. 2022. Both Sides of a Coin: Having Open Heart Surgery While Researching in Cardiology. JACC: Case Reports. 4 (22), pp. 1556-1558. https://doi.org/10.1016/j.jaccas.2022.08.041
One year of isometric exercise training for blood pressure management in men: a prospective randomized controlled study
O'Driscoll, J. M., Edwards, J. J., Coleman, D. A., Taylor, K. A., Sharma, R. and Wiles, J. D. 2022. One year of isometric exercise training for blood pressure management in men: a prospective randomized controlled study. Journal of Hypertension. 40 (12), pp. 2406-2412. https://doi.org/10.1097/HJH.0000000000003269
Mechanisms for blood pressure reduction following isometric exercise training: a systematic review and meta-analysis
Edwards, J. J., Wiles, J. and O'Driscoll, J. 2022. Mechanisms for blood pressure reduction following isometric exercise training: a systematic review and meta-analysis. Journal of Hypertension. 40 (11), pp. 2299-2306. https://doi.org/10.1097/HJH.0000000000003261
Myocardial work and left ventricular mechanical adaptations following isometric exercise training in hypertensive patients
O'Driscoll, J. M., Edwards, J. J., Wiles, J. D., Tylor, K. A., Leeson, P. and Sharma, R. 2022. Myocardial work and left ventricular mechanical adaptations following isometric exercise training in hypertensive patients. European Journal of Applied Physiology. 122, pp. 727-734. https://doi.org/10.1007/s00421-021-04882-3
Left ventricular mechanical, cardiac autonomic and metabolic responses to a single session of high intensity interval training
Edwards, J. J., Wiles, J. D., Vadaszy, N., Taylor, K. A. and O'Driscoll, J. M. 2022. Left ventricular mechanical, cardiac autonomic and metabolic responses to a single session of high intensity interval training. European Journal of Applied Physiology. 122, pp. 383-394. https://doi.org/10.1007/s00421-021-04840-z
Blood pressure and cardiac autonomic adaptations to isometric exercise training: A randomized sham‐controlled study
Decaux, A, Edwards, J. J., Swift, H. T., Hurst, P., Hopkins, J., Wiles, J. D. and O'Driscoll, J. M. 2022. Blood pressure and cardiac autonomic adaptations to isometric exercise training: A randomized sham‐controlled study. Physiological Reports. 10 (2), p. e15112. https://doi.org/10.14814/phy2.15112
Isometric exercise versus high-intensity interval training for the management of blood pressure: a systematic review and meta-analysis
Edwards, J., Decaux, A., Donaldson, J., Wiles, J. and O'Driscoll, J. 2022. Isometric exercise versus high-intensity interval training for the management of blood pressure: a systematic review and meta-analysis. British Journal of Sports Medicine. 56, pp. 506-514. https://doi.org/10.1136/bjsports-2021-104642
Myocardial Mechanics in Hypertensive Disorders of Pregnancy: a Systematic Review and Meta-Analysis
O'Driscoll, J., Giogione, V., Edwards, J., Wiles, J., Sharma, R. and Thilaganathan, B. 2022. Myocardial Mechanics in Hypertensive Disorders of Pregnancy: a Systematic Review and Meta-Analysis. Hypertension. 79 (2), pp. 391-398. https://doi.org/10.1161/HYPERTENSIONAHA.121.18123
Risk of atrial fibrillation in athletes: a systematic review and meta-analysis
Newman W., Parry-Williams, G., Wiles, J., Edwards, J., Hulbert, S., Kipourou, K., Papadakis, M., Sharma, R. and O'Driscoll, J. 2022. Risk of atrial fibrillation in athletes: a systematic review and meta-analysis. British Journal of Sports Medicine. 55, pp. 1233-1238. https://doi.org/10.1136/bjsports-2021-103994
Ambulatory blood pressure adaptations to high-intensity interval training: A randomized controlled study
Edwards, J., Taylor, K, Cottam, C, Jalaludeen, N, Coleman, D, Wiles, J, Sharma, R and O'Driscoll, J. 2021. Ambulatory blood pressure adaptations to high-intensity interval training: A randomized controlled study. Journal of Hypertension. 39 (2), pp. 341-348. https://doi.org/10.1097/HJH.0000000000002630