Association between sleep disturbances and challenging behavior in children and adolescents with Angelman syndrome

Article

O'Donohoe, D. S., Whelan, S., Mannion, A., Tones, M., Heussler, H., Bellgard, M. and Leader, G. 2024. Association between sleep disturbances and challenging behavior in children and adolescents with Angelman syndrome. Sleep Medicine. 123, pp. 1-6. https://doi.org/10.1016/j.sleep.2024.07.033
AuthorsO'Donohoe, D. S., Whelan, S., Mannion, A., Tones, M., Heussler, H., Bellgard, M. and Leader, G.
Abstract

Angelman Syndrome (AS) is a neurodevelopmental disorder with severe symptoms and associated comorbidities. It is caused by the inactivity or lack of the UBE3a gene. Symptoms of the syndrome include intellectual disability
and developmental delay.
The current study investigated sleep disturbances (SD) in children and adolescents with AS, associations between SD and possible predictors of SD. Variables examined included age, gender, newborn and infancy history, challenging behavior, type of therapy received, genetic type of AS, and seizures. The sample included data from 109 participants with a mean age of 8.21, accessed via the Global Angelman Syndrome Registry. Chi-square tests were carried out to assess the associations between the variables and a logistical regression was carried out to assess the possible predictors of SD. Associations were found between SD and certain repetitive behaviors: slapping walls, focal hand movements, and agitation at new situations. From these associations, a regression formed a predictive model for sleep disturbances. The findings of this research demonstrated the importance of investigating the relationship between sleep disturbances and challenging behavior in children and adolescents with AS and the need for further research in this area.

JournalSleep Medicine
Journal citation123, pp. 1-6
ISSN1878-5506
Year2024
PublisherElsevier
Accepted author manuscript
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File Access Level
Anyone
Digital Object Identifier (DOI)https://doi.org/10.1016/j.sleep.2024.07.033
Publication dates
Online22 Aug 2024
Publication process dates
Accepted26 Jul 2024
Deposited20 Feb 2025
Copyright holder© 2024 Elsevier
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