Association Between Feeding Problems and Gastrointestinal Symptoms, Language, and Developmental History in Adults With Angelman Syndrome

Article


Cassidy, C., Mannion, A., Whelan, S., Tones, M., Heussler, H., Bellgard, M. and Leader, G. 2025. Association Between Feeding Problems and Gastrointestinal Symptoms, Language, and Developmental History in Adults With Angelman Syndrome. American Journal of Medical Genetics Part A. (Art. e64137). https://doi.org/10.1002/ajmg.a.64137
AuthorsCassidy, C., Mannion, A., Whelan, S., Tones, M., Heussler, H., Bellgard, M. and Leader, G.
Abstract

Angelman syndrome (AS) is a neurodevelopmental disorder characterized by severe developmental delays, typical facial features, ataxia, seizures, speech impairments, sleeping difficulties, and a happy demeanor. Caregivers of individuals with AS often report feeding problems, with difficulties including issues with obesity, failure to gain weight at the expected rate, food-seeking behaviors, and the requirement of tube-feeding. This study examined the frequency of feeding problems in 57 adults with AS, the most common types of issues, the associations and differences between those who experience feeding problems, and the predictors of feeding problems. Caregivers provided information through the Global Angelman Syndrome Registry, a global database that gathers information on individuals with AS. High rates of feeding problems were found, with 83% of adults experiencing feeding problems. The most common issue reported was food-seeking behaviors. Analyses found significant associations between feeding problems and gastrointestinal symptoms, and language and communication. Analyses did not find these variables to significantly predict feeding problems in adults with AS. The results of this study extend the current literature by highlighting the variables that are associated with feeding problems, the most common types of problems, and the high rates of feeding problems among adults with AS.

JournalAmerican Journal of Medical Genetics Part A
Journal citation(Art. e64137)
ISSN1552-4833
Year2025
PublisherWiley
Publisher's version
License
File Access Level
Anyone
Digital Object Identifier (DOI)https://doi.org/10.1002/ajmg.a.64137
Publication dates
Online29 Jun 2025
Publication process dates
Accepted25 May 2025
Deposited01 Jul 2025
Copyright holder© 2025 The Authors
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