Dr Jay Ruchaya

NameDr Jay Ruchaya
ORCIDhttps://orcid.org/0000-0001-9580-4746
Job titleSenior Lecturer
Email addressp.j.ruchaya@uel.ac.uk
Research instituteHealth, Sport & Bioscience

Research outputs

From bench to bedside: The critical need for standardized senescence detection

Shah, J., Al-Hashimi, A., Benedetto, M. and Ruchaya, P. J. 2025. From bench to bedside: The critical need for standardized senescence detection. Archives of Cardiovascular Diseases. 118 (3), pp. 205-211. https://doi.org/10.1016/j.acvd.2024.12.008

Correction: Transplantation of Skeletal Muscle-Derived Sca-1⁺/PW1⁺/Pax7⁻ Interstitial Cells (PICs) Improves Cardiac Function and Attenuates Remodeling in Mice Subjected to Myocardial Infarction. Cells 2022, 11, 4050

Ruchaya, J., Lewis-McDougall, F. C., Sornkarn, N., Amin, S., Grimsdell, B., Shaalan, A., Gritti, G., Soe, K. T., Clark, J. E. and Ellison-Hughes, G. M. 2024. Correction: Transplantation of Skeletal Muscle-Derived Sca-1⁺/PW1⁺/Pax7⁻ Interstitial Cells (PICs) Improves Cardiac Function and Attenuates Remodeling in Mice Subjected to Myocardial Infarction. Cells 2022, 11, 4050. Cells. 13 (11), p. 895. https://doi.org/10.3390/cells13110895

Return of the Tbx5; lineage-tracing reveals ventricular cardiomyocyte-like precursors in the injured adult mammalian heart

Siatra, P., Vatsellas, G., Chatzianastasiou, A., Balafas, E., Manolakou, T., Papapetropoulos, A., Agapaki, A., Mouchtouri, A-T., Ruchaya, P. J., Korovesi, A. G., Mavroidis, M., Thanos, D., Beis, D. and Kokkinopoulos, I. 2023. Return of the Tbx5; lineage-tracing reveals ventricular cardiomyocyte-like precursors in the injured adult mammalian heart. NPJ Regenerative Medicine. 8 (Art. 13). https://doi.org/10.1038/s41536-023-00280-9

Transplantation of Skeletal Muscle-Derived Sca-1⁺/PW1⁺/Pax7⁻ Interstitial Cells (PICs) Improves Cardiac Function and Attenuates Remodeling in Mice Subjected to Myocardial Infarction

Ruchaya, P. J., Lewis-McDougall, F. C., Sornkarn, N., Amin, S., Grimsdell, B., Shaalan, A., Gritti, G., Soe, K. T., Clark, J. E. and Ellison-Hughes, G. M. 2022. Transplantation of Skeletal Muscle-Derived Sca-1⁺/PW1⁺/Pax7⁻ Interstitial Cells (PICs) Improves Cardiac Function and Attenuates Remodeling in Mice Subjected to Myocardial Infarction. Cells. 11 (24), p. 4050. https://doi.org/https://doi.org/10.3390/cells11244050

Receptor tyrosine kinase inhibitors negatively impact on pro-reparative characteristics of human cardiac progenitor cells

Smith, A. J., Ruchaya, P. J., Walmsley, R., Wright, K. E., Lewis-McDougall, F. C., Bond, J. and Ellison-Hughes, G. M. 2022. Receptor tyrosine kinase inhibitors negatively impact on pro-reparative characteristics of human cardiac progenitor cells. Scientific Reports. 12 (Art. 10132). https://doi.org/https://doi.org/10.1038/s41598-022-13203-3

Aged-senescent cells contribute to impaired heart regeneration

Lewis-McDougall, F. C., Ruchaya, P. J., Domenjo-Vila, E., Teoh, T. S., Prata, L., Cottle, B. J., Clark, J. E., Punjabi, P. P., Awad, W., Torella, D., Tchkonia, T., Kirkland, J. L. and Ellison-Hughes, G. M. 2019. Aged-senescent cells contribute to impaired heart regeneration. Aging Cell. 18 (3), p. Art. e12931. https://doi.org/10.1111/acel.12931
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