Validation of a HPLC method for flavonoid biomarkers in skullcap (Scutellaria) and its use to illustrate wide variability in the quality of commercial tinctures

Article


Gao, Jiayu, Sanchez-Medina, Alberto, Pendry, B., Hughes, Michael J., Webb, Geoffrey P. and Corcoran, Olivia 2008. Validation of a HPLC method for flavonoid biomarkers in skullcap (Scutellaria) and its use to illustrate wide variability in the quality of commercial tinctures. Journal of Pharmacy and Pharmaceutical Sciences. 11 (1), pp. 77-87.
AuthorsGao, Jiayu, Sanchez-Medina, Alberto, Pendry, B., Hughes, Michael J., Webb, Geoffrey P. and Corcoran, Olivia
Abstract

This paper compares the flavonoid biomarker content (baicalin, baicalein and wogonin) of eleven commercial tinctures derived from Scutellaria lateriflora aerial parts
(n=7) and Scutellaria baicalensis root (n=4). S. lateriflora tinctures are used by Western herbal practitioners to treat anxiety whereas S. baicalensis tinctures are used to treat inflammatory disease. It’s findings indicate that the wide variability in biomarker concentrations between commercial tinctures has important implications for the manufacturers of commercial tinctures, for herbal practitioners in the choice of tinctures and not least for pharmacology and clinical researchers.

Keywordsbiomarkers; inflammatory disease; Western herbal practitioners; anxiety; clinical research; commercial tinctures
JournalJournal of Pharmacy and Pharmaceutical Sciences
Journal citation11 (1), pp. 77-87
ISSN1482-1826
Year2008
Publisher's version
License
CC BY-ND
Web address (URL)http://hdl.handle.net/10552/242
Publication dates
Print2008
Publication process dates
Deposited10 Aug 2009
Additional information

Citation:
Gao, J. et al (2008) ‘Validation of a HPLC method for flavonoid biomarkers in skullcap (Scutellaria) and its use to illustrate wide variability in the quality of commercial tinctures.’ Journal of Pharmacy and Pharmaceutical Sciences 11 (1) 77-87.

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