Terpenes from Zingiber montanum and Their Screening against Multi-Drug Resistant and Methicillin Resistant Staphylococcus aureus

Article

Siddique, H., Pendry, B. and Rahman, M. 2019. Terpenes from Zingiber montanum and Their Screening against Multi-Drug Resistant and Methicillin Resistant Staphylococcus aureus. Molecules. 24 (3), p. Art. 385. https://doi.org/10.3390/molecules24030385
AuthorsSiddique, H., Pendry, B. and Rahman, M.
Abstract

Bioassay directed isolation of secondary metabolites from the rhizomes of Zingiber montanum (Fam. ‎Zingiberaceae) led to the isolation of mono-, sesqui-, and di-terpenes. The compounds were characterized as (E)-8(17),12-labdadiene-15,16-dial (1), zerumbol (2), zerumbone (3), buddledone A (4), furanodienone (5), germacrone (6), borneol (7), and camphor (8) by analysing one-dimensional (1D) (¹H and ¹³C) and two-dimensional (2D) (COSY, HSQC, HMBC, and NOESY) NMR data and mass spectra. Among these terpenes, compounds 1 and 2 revealed potential antibacterial activity (minimum inhibitory concentrations (MIC) values 32–128 µg/mL; 0.145–0.291 mM)) against a series of clinical isolates of multi-drug resistant (MDR) and Methicillin resistant Staphylococcus aureus (MRSA).

JournalMolecules
Journal citation24 (3), p. Art. 385
ISSN1420-3049
Year2019
PublisherMDPI
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Digital Object Identifier (DOI)https://doi.org/10.3390/molecules24030385
Web address (URL)https://doi.org/10.3390/molecules24030385
Publication dates
Print22 Jan 2019
Publication process dates
Deposited11 Feb 2019
Accepted20 Jan 2019
Accepted20 Jan 2019
Copyright information© 2019 The authors
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