Terpenes from Zingiber montanum and Their Screening against Multi-Drug Resistant and Methicillin Resistant Staphylococcus aureus
Article
Siddique, H., Pendry, B. and Rahman, M. 2019. Terpenes from Zingiber montanum and Their Screening against Multi-Drug Resistant and Methicillin Resistant Staphylococcus aureus. Molecules. 24 (3), p. Art. 385. https://doi.org/10.3390/molecules24030385
Authors | Siddique, H., Pendry, B. and Rahman, M. |
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Abstract | Bioassay directed isolation of secondary metabolites from the rhizomes of Zingiber montanum (Fam. Zingiberaceae) led to the isolation of mono-, sesqui-, and di-terpenes. The compounds were characterized as (E)-8(17),12-labdadiene-15,16-dial (1), zerumbol (2), zerumbone (3), buddledone A (4), furanodienone (5), germacrone (6), borneol (7), and camphor (8) by analysing one-dimensional (1D) (¹H and ¹³C) and two-dimensional (2D) (COSY, HSQC, HMBC, and NOESY) NMR data and mass spectra. Among these terpenes, compounds 1 and 2 revealed potential antibacterial activity (minimum inhibitory concentrations (MIC) values 32–128 µg/mL; 0.145–0.291 mM)) against a series of clinical isolates of multi-drug resistant (MDR) and Methicillin resistant Staphylococcus aureus (MRSA). |
Journal | Molecules |
Journal citation | 24 (3), p. Art. 385 |
ISSN | 1420-3049 |
Year | 2019 |
Publisher | MDPI |
Publisher's version | License |
Supplemental file | |
Digital Object Identifier (DOI) | https://doi.org/10.3390/molecules24030385 |
Web address (URL) | https://doi.org/10.3390/molecules24030385 |
Publication dates | |
22 Jan 2019 | |
Publication process dates | |
Deposited | 11 Feb 2019 |
Accepted | 20 Jan 2019 |
Accepted | 20 Jan 2019 |
Copyright information | © 2019 The authors |
https://repository.uel.ac.uk/item/844yw
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