Terpenes from Zingiber montanum and Their Screening against Multi-Drug Resistant and Methicillin Resistant Staphylococcus aureus

Article


Siddique, H., Pendry, B. and Rahman, M. 2019. Terpenes from Zingiber montanum and Their Screening against Multi-Drug Resistant and Methicillin Resistant Staphylococcus aureus. Molecules. 24 (3), p. Art. 385.
AuthorsSiddique, H., Pendry, B. and Rahman, M.
Abstract

Bioassay directed isolation of secondary metabolites from the rhizomes of Zingiber montanum (Fam. ‎Zingiberaceae) led to the isolation of mono-, sesqui-, and di-terpenes. The compounds were characterized as (E)-8(17),12-labdadiene-15,16-dial (1), zerumbol (2), zerumbone (3), buddledone A (4), furanodienone (5), germacrone (6), borneol (7), and camphor (8) by analysing one-dimensional (1D) (¹H and ¹³C) and two-dimensional (2D) (COSY, HSQC, HMBC, and NOESY) NMR data and mass spectra. Among these terpenes, compounds 1 and 2 revealed potential antibacterial activity (minimum inhibitory concentrations (MIC) values 32–128 µg/mL; 0.145–0.291 mM)) against a series of clinical isolates of multi-drug resistant (MDR) and Methicillin resistant Staphylococcus aureus (MRSA).

JournalMolecules
Journal citation24 (3), p. Art. 385
ISSN1420-3049
Year2019
PublisherMDPI
Publisher's version
License
Supplemental file
Digital Object Identifier (DOI)doi:10.3390/molecules24030385
Web address (URL)https://doi.org/10.3390/molecules24030385
Publication dates
Print22 Jan 2019
Publication process dates
Deposited11 Feb 2019
Accepted20 Jan 2019
Accepted20 Jan 2019
Copyright information© 2019 The authors
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