Antimicrobial Natural Products

Book chapter

Rahman, M. and Sarker, S. 2020. Antimicrobial Natural Products. in: Sarker, S. and Nahar, L. (ed.) Medicinal Natural Products: A Disease-Focused Approach, Volume 55 Academic Press. pp. 77-113
AuthorsRahman, M. and Sarker, S.
EditorsSarker, S. and Nahar, L.
Abstract

Although the first antibiotic, penicillin, was discovered in 1928 from a microbial natural source (a mould, Penicillium notatum), there is earlier evidence of using natural materials including moulds and herbs for the treatment of infections. Following the serendipitous discovery of penicillin by Alexander Fleming, there have been hundreds of antibiotics (natural, semisynthetic and synthetic) discovered for clinical uses. However, the pathogenic organisms have developed resistances to existing antibiotics though various mechanisms. Such antibiotic resistance or antimicrobial resistance (AMR) is a critical problem of today’s healthcare system urging the development of new antibiotics. This chapter has primarily focused into antimicrobial compounds developed through natural routes that are currently available as antibiotics for clinical uses and/or are at various developmental stages within the drug development pipeline for potential treatment of minor and life threatening infections. The chapter also provides an overview on the catastrophic problem of antimicrobial resistance, its causes, how it spreads as well as modes of developing antimicrobial resistance (AMR).

Book titleMedicinal Natural Products: A Disease-Focused Approach, Volume 55
Page range77-113
Year2020
PublisherAcademic Press
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Publication dates
Print21 Sep 2020
Publication process dates
Deposited09 Jun 2020
SeriesAnnual Reports in Medicinal Chemistry
ISBN9780128210192
ISSN0065-7743
Digital Object Identifier (DOI)https://doi.org/10.1016/bs.armc.2020.06.001
Web address (URL)https://www.elsevier.com/books/medicinal-natural-products-a-disease-focused-approach/sarker/978-0-12-821019-2
Copyright holder© Academic Press 2020
Copyright informationThis is the accepted manuscript of the following chapter: Rahman, M. and Sarker, S. 2020. Antimicrobial Natural Products. To be published in: Sarker, S. and Nahar, L. (ed.) Medicinal Natural Products: A Disease-Focused Approach, Volume 55 Academic Press. https://www.elsevier.com/books/medicinal-natural-products-a-disease-focused-approach/sarker/978-0-12-821019-2.
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