Antimicrobial resistance and synergy in herbal medicine

Article

Mundy, Lorna, Pendry, Barbara and Rahman, M. 2016. Antimicrobial resistance and synergy in herbal medicine. Journal of Herbal Medicine. 6 (2), pp. 53-58. https://doi.org/10.1016/j.hermed.2016.03.001
AuthorsMundy, Lorna, Pendry, Barbara and Rahman, M.
Abstract

Antimicrobial resistance (AMR) is a serious and growing threat to human health. The development
of new antibiotics is limited and slow. The tradition of synergy in herbal medicine is being used
as a source of research ideas. A literature review of antimicrobial research and plant synergy
published in a five year period was carried out using online databases. The in vitro findings were
that most of the research reported synergy both within plants and between plants and antibiotics.
Whole plant extracts and combinations of compounds were shown to be more effective
antimicrobials than isolated constituents. The discussion highlights that the in vitro herbal
research findings are difficult to apply to practice and aren’t progressing to clinical trials.
Collaborative, innovative, inter-disciplinary clinical research is recommended.

JournalJournal of Herbal Medicine
Journal citation6 (2), pp. 53-58
ISSN22108033
Year2016
PublisherElsevier
Accepted author manuscript
License
CC BY-NC-ND
Digital Object Identifier (DOI)https://doi.org/10.1016/j.hermed.2016.03.001
Publication dates
Print05 Mar 2016
Publication process dates
Deposited14 Mar 2016
Accepted01 Mar 2016
Permalink -

https://repository.uel.ac.uk/item/85202

Log in to edit

Download files

Accepted author manuscript
AMR_paper final version_JHM.pdf
License: CC BY-NC-ND

  • 262
    total views
  • 1141
    total downloads
  • 10
    views this month
  • 20
    downloads this month

Export as

Related outputs

Antileprotic drugs
Shaik, A. B. and Rahman, M. 2023. Antileprotic drugs. in: Acharya, P. C. and Kurosu, M. (ed.) Medicinal Chemistry of Chemotherapeutic Agents: A Comprehensive Resource of Anti-Infective and Anti-cancer Drugs Academic Press. pp. 267-282
Antitubercular drugs
Shaik, A. B. and Rahman, M. 2023. Antitubercular drugs. in: Acharya, P. C. and Kurosu, M. (ed.) Medicinal Chemistry of Chemotherapeutic Agents: A Comprehensive Resource of Anti-Infective and Anti-cancer Drugs Academic Press. pp. 217-265
Bioactivity and In Silico Studies of Isoquinoline and Related Alkaloids as Promising Antiviral Agents: An Insight
Sharma, D., Sharma, N., Manchanda, N., Prasad, S. K., Sharma, P. C., Thakur, V. K., Rahman, M. and Dhobi, M. 2022. Bioactivity and In Silico Studies of Isoquinoline and Related Alkaloids as Promising Antiviral Agents: An Insight. Biomolecules. 13 (1), p. Art. 17. https://doi.org/10.3390/biom13010017
Editorial: Natural products as potential therapeutics to tackle life-threatening infections: From field to market
Rahman, M. 2022. Editorial: Natural products as potential therapeutics to tackle life-threatening infections: From field to market. Frontiers in Pharmacology. 13 (Art. 1099181). https://doi.org/10.3389/fphar.2022.1099181
Antitubercular activity assessment of fluorinated chalcones, 2-aminopyridine-3-carbonitrile and 2-amino-4H-pyran-3-carbonitrile derivatives: In vitro, molecular docking and in-silico drug likeliness studies
Lagu, S. B., Yejella, R. P., Nissankararao, S., Bhandare, R. R., Golla, V. S., Subrahmanya Lokesh, B. V., Rahman, M. and Shaik, A. B. 2022. Antitubercular activity assessment of fluorinated chalcones, 2-aminopyridine-3-carbonitrile and 2-amino-4H-pyran-3-carbonitrile derivatives: In vitro, molecular docking and in-silico drug likeliness studies. PLoS ONE. 17 (Art. e0265068). https://doi.org/10.1371/journal.pone.0265068
Antimicrobial Diterpenes: Recent Development From Natural Sources
Saha, P., Rahman, F. I., Hussain, F., Rahman, S. M. A. and Rahman, M. 2022. Antimicrobial Diterpenes: Recent Development From Natural Sources. Frontiers in Pharmacology. 12 (Art. 820312). https://doi.org/10.3389/fphar.2021.820312
Medicinal plants used to treat infectious diseases in the central part and a northern district of Bangladesh - an ethnopharmacological perception
Siddique, H., Pendry, B., Rashid, M. A. and Rahman, M. 2021. Medicinal plants used to treat infectious diseases in the central part and a northern district of Bangladesh - an ethnopharmacological perception. Journal of Herbal Medicine. 29 (Art. 100484). https://doi.org/10.1016/j.hermed.2021.100484
Anti-MRSA Constituents from Ruta chalepensis (Rutaceae) Grown in Iraq, and In Silico Studies on Two of Most Active Compounds, Chalepensin and 6-Hydroxy-rutin 3’,7-Dimethyl ether
Al-Majmaie, S., Nahar, L., Rahman, M., Nath, S., Saha, P., Talukdar, A. D., Sharples, G. P. and Sarker, S. D. 2021. Anti-MRSA Constituents from Ruta chalepensis (Rutaceae) Grown in Iraq, and In Silico Studies on Two of Most Active Compounds, Chalepensin and 6-Hydroxy-rutin 3’,7-Dimethyl ether. Molecules. 26 (Art. 1114). https://doi.org/10.3390/molecules26041114
Synthesis, and biological screening of chloropyrazine conjugated benzothiazepine derivatives as potential antimicrobial, antitubercular and cytotoxic agents
Shaik, A. B., Bhandare, R. R., Nissankararao, S., Lokesh, B. V. S., Shahanaaz, S. and Rahman, M. 2020. Synthesis, and biological screening of chloropyrazine conjugated benzothiazepine derivatives as potential antimicrobial, antitubercular and cytotoxic agents. Arabian Journal of Chemistry. 14 (Art. 102915). https://doi.org/10.1016/j.arabjc.2020.102915
Design, Facile Synthesis and Characterization of Dichloro Substituted Chalcones and Dihydropyrazole Derivatives for Their Antifungal, Antitubercular and Antiproliferative Activities
Shaik, A. B., Bhandare, R. R., Nissankararao, S., Edis, Z., Tangirala, N. R., Shahanaaz, S. and Rahman, M. 2020. Design, Facile Synthesis and Characterization of Dichloro Substituted Chalcones and Dihydropyrazole Derivatives for Their Antifungal, Antitubercular and Antiproliferative Activities. Molecules. 25 (Art. 3188). https://doi.org/10.3390/molecules25143188
Antimicrobial Natural Products
Rahman, M. and Sarker, S. 2020. Antimicrobial Natural Products. in: Sarker, S. and Nahar, L. (ed.) Medicinal Natural Products: A Disease-Focused Approach, Volume 55 Academic Press. pp. 77-113
Terpenes from Zingiber montanum and Their Screening against Multi-Drug Resistant and Methicillin Resistant Staphylococcus aureus
Siddique, H., Pendry, B. and Rahman, M. 2019. Terpenes from Zingiber montanum and Their Screening against Multi-Drug Resistant and Methicillin Resistant Staphylococcus aureus. Molecules. 24 (3), p. Art. 385. https://doi.org/10.3390/molecules24030385
Total synthesis of acylphloroglucinols and their antibacterial activities against clinical isolates of multi-drug resistant (MDR) and methicillin-resistant strains of Staphylococcus aureus
Rahman, M., Shiu, Winnie K.P., Gibbons, Simon and Malkinson, John P. 2018. Total synthesis of acylphloroglucinols and their antibacterial activities against clinical isolates of multi-drug resistant (MDR) and methicillin-resistant strains of Staphylococcus aureus. European Journal of Medicinal Chemistry. 155, pp. 255-262. https://doi.org/10.1016/j.ejmech.2018.05.038
Antimicrobial Secondary Metabolites—Extraction, Isolation, Identification, and Bioassay
Rahman, M. 2015. Antimicrobial Secondary Metabolites—Extraction, Isolation, Identification, and Bioassay. in: Evidence-Based Validation of Herbal Medicine Elsevier. pp. 495-513
Analogues of Disulfides from Allium stipitatum Demonstrate Potent Anti-tubercular Activities through Drug Efflux Pump and Biofilm Inhibition
Danquah, Cynthia A., Kakagianni, Eleftheria, Khondkar, Proma, Maitra, Arundhati, Rahman, M., Evangelopoulos, Dimitrios, McHugh, Timothy D., Stapleton, Paul, Malkinson, John, Bhakta, Sanjib and Gibbons, Simon 2018. Analogues of Disulfides from Allium stipitatum Demonstrate Potent Anti-tubercular Activities through Drug Efflux Pump and Biofilm Inhibition. Scientific Reports. 8 (1150). https://doi.org/10.1038/s41598-017-18948-w
Anti-Staphylococcal Calopins from Fruiting Bodies of Caloboletus radicans
Tareq, F. S., Hasan, C. M., Rahman, M., Hanafi, M. M., Ciacchi, L. C., Michaelis, M., Harder, T., Tebben, J., Islam, M. T. and Spiteller, P. 2018. Anti-Staphylococcal Calopins from Fruiting Bodies of Caloboletus radicans. Journal of Natural Products. 81 (2), pp. 400-404. https://doi.org/10.1021/acs.jnatprod.7b00525
Application of computational methods in isolation of plant secondary metabolites
Rahman, M. 2018. Application of computational methods in isolation of plant secondary metabolites. in: Sarker, Satyajit and Nahar, Lutfun (ed.) Computational Phytochemistry Elsevier.
Anti-MRSA Activity of Oxysporone and Xylitol from the Endophytic Fungus Pestalotia sp. Growing on the Sundarbans Mangrove Plant Heritiera fomes
Nurunnabi, Tauhidur Rahman, Nahar, Lutfun, Al-Majmaie, Shaymaa, Mahbubur Rahman, S. M., Sohrab, Md. Hossain, Billah, Md. Morsaline, Ismail, Fyaz M.D., Rahman, M., Sharples, George P. and Sarker, Satyajit D. 2017. Anti-MRSA Activity of Oxysporone and Xylitol from the Endophytic Fungus Pestalotia sp. Growing on the Sundarbans Mangrove Plant Heritiera fomes. Phytotherapy Research. 32 (2), pp. 348-354. https://doi.org/10.1002/ptr.5983
Antibacterial constituents of Neohyptis paniculata
Rahman, M. and Gibbons, Simon 2015. Antibacterial constituents of Neohyptis paniculata. Fitoterapia. 105, pp. 269-272.
Conversion of salvianolic acid B into salvianolic acid A in tissues of Radix Salviae Miltiorrhizae using high temperature, high pressure and high humidity
Xia, Hongrui, Sun, Longru, Lou, Hongxiang and Rahman, M. 2014. Conversion of salvianolic acid B into salvianolic acid A in tissues of Radix Salviae Miltiorrhizae using high temperature, high pressure and high humidity. Phytomedicine.