Bioactivity and In Silico Studies of Isoquinoline and Related Alkaloids as Promising Antiviral Agents: An Insight
Article
Sharma, D., Sharma, N., Manchanda, N., Prasad, S. K., Sharma, P. C., Thakur, V. K., Rahman, M. and Dhobi, M. 2022. Bioactivity and In Silico Studies of Isoquinoline and Related Alkaloids as Promising Antiviral Agents: An Insight. Biomolecules. 13 (1), p. Art. 17. https://doi.org/10.3390/biom13010017
Authors | Sharma, D., Sharma, N., Manchanda, N., Prasad, S. K., Sharma, P. C., Thakur, V. K., Rahman, M. and Dhobi, M. |
---|---|
Abstract | Viruses are widely recognized as the primary cause of infectious diseases around the world. The ongoing global pandemic due to the emergence of SARS-CoV-2 further added fuel to the fire. The development of therapeutics becomes very difficult as viruses can mutate their genome to become more complex and resistant. Medicinal plants and phytocompounds could be alternative options. Isoquinoline and their related alkaloids are naturally occurring compounds that interfere with multiple pathways including nuclear factor-κB, mitogen-activated protein kinase/extracellular-signal-regulated kinase, and inhibition of Ca²⁺-mediated fusion. These pathways play a crucial role in viral replication. Thus, the major goal of this study is to comprehend the function of various isoquinoline and related alkaloids in viral infections by examining their potential mechanisms of action, structure-activity relationships (SAR), in silico (particularly for SARS-CoV-2), in vitro and in vivo studies. The current advancements in isoquinoline and related alkaloids as discussed in the present review could facilitate an in-depth understanding of their role in the drug discovery process. |
Journal | Biomolecules |
Journal citation | 13 (1), p. Art. 17 |
ISSN | 2218-273X |
Year | 2022 |
Publisher | MDPI |
Publisher's version | License File Access Level Anyone |
Digital Object Identifier (DOI) | https://doi.org/10.3390/biom13010017 |
Publication dates | |
Online | 21 Dec 2022 |
Publication process dates | |
Accepted | 15 Nov 2022 |
Deposited | 31 May 2023 |
Copyright holder | © 2022, The Author(s) |
https://repository.uel.ac.uk/item/8w124
Download files
97
total views110
total downloads3
views this month2
downloads this month