Antimicrobial Secondary Metabolites—Extraction, Isolation, Identification, and Bioassay

Book chapter


Rahman, M. 2015. Antimicrobial Secondary Metabolites—Extraction, Isolation, Identification, and Bioassay. in: Evidence-Based Validation of Herbal Medicine Elsevier. pp. 495-513
AuthorsRahman, M.
Abstract

The golden era of antibiotics started after the accidental discovery of penicillin by Alexander Fleming. An enormous number of antibiotics have been discovered to tackle various types of infections. However, microorganisms are continuing to develop resistance to the existing antibiotics. Because of this antibiotic-resistance issue, infectious diseases are still considered as the second leading causes of death globally and amount to approximately 17 million deaths every year. To tackle antimicrobial resistance, one has to obviously focus on natural resources for the discovery and development of safer and effective antimicrobial agents. This chapter starts with a brief history of antibiotics followed by the common methods that can be used systematically for bioassay-directed isolation and identification of antimicrobial secondary metabolites. Some examples of naturally derived antimicrobial secondary metabolites have also been included in this chapter.

Book titleEvidence-Based Validation of Herbal Medicine
Page range495-513
Year2015
PublisherElsevier
Publication dates
Online03 Apr 2015
Publication process dates
Deposited23 Feb 2018
Digital Object Identifier (DOI)https://doi.org/10.1016/B978-0-12-800874-4.00023-4
Web address (URL)https://doi.org/10.1016/B978-0-12-800874-4.00023-4
Permalink -

https://repository.uel.ac.uk/item/85688

  • 110
    total views
  • 0
    total downloads
  • 8
    views this month
  • 0
    downloads this month

Export as

Related outputs

Medicinal plants used to treat infectious diseases in the central part and a northern district of Bangladesh - an ethnopharmacological perception
Siddique, H., Pendry, B., Rashid, M. A. and Rahman, M. 2021. Medicinal plants used to treat infectious diseases in the central part and a northern district of Bangladesh - an ethnopharmacological perception. Journal of Herbal Medicine. 29 (Art. 100484). https://doi.org/10.1016/j.hermed.2021.100484
Anti-MRSA Constituents from Ruta chalepensis (Rutaceae) Grown in Iraq, and In Silico Studies on Two of Most Active Compounds, Chalepensin and 6-Hydroxy-rutin 3’,7-Dimethyl ether
Al-Majmaie, S., Nahar, L., Rahman, M., Nath, S., Saha, P., Talukdar, A. D., Sharples, G. P. and Sarker, S. D. 2021. Anti-MRSA Constituents from Ruta chalepensis (Rutaceae) Grown in Iraq, and In Silico Studies on Two of Most Active Compounds, Chalepensin and 6-Hydroxy-rutin 3’,7-Dimethyl ether. Molecules. 26 (Art. 1114). https://doi.org/10.3390/molecules26041114
Synthesis, and biological screening of chloropyrazine conjugated benzothiazepine derivatives as potential antimicrobial, antitubercular and cytotoxic agents
Shaik, A. B., Bhandare, R. R., Nissankararao, S., Lokesh, B. V. S., Shahanaaz, S. and Rahman, M. 2020. Synthesis, and biological screening of chloropyrazine conjugated benzothiazepine derivatives as potential antimicrobial, antitubercular and cytotoxic agents. Arabian Journal of Chemistry. 14 (Art. 102915). https://doi.org/10.1016/j.arabjc.2020.102915
Design, Facile Synthesis and Characterization of Dichloro Substituted Chalcones and Dihydropyrazole Derivatives for Their Antifungal, Antitubercular and Antiproliferative Activities
Shaik, A. B., Bhandare, R. R., Nissankararao, S., Edis, Z., Tangirala, N. R., Shahanaaz, S. and Rahman, M. 2020. Design, Facile Synthesis and Characterization of Dichloro Substituted Chalcones and Dihydropyrazole Derivatives for Their Antifungal, Antitubercular and Antiproliferative Activities. Molecules. 25 (Art. 3188). https://doi.org/10.3390/molecules25143188
Antimicrobial Natural Products
Rahman, M. and Sarker, S. 2020. Antimicrobial Natural Products. in: Sarker, S. and Nahar, L. (ed.) Medicinal Natural Products: A Disease-Focused Approach, Volume 55 Academic Press. pp. 77-113
Terpenes from Zingiber montanum and Their Screening against Multi-Drug Resistant and Methicillin Resistant Staphylococcus aureus
Siddique, H., Pendry, B. and Rahman, M. 2019. Terpenes from Zingiber montanum and Their Screening against Multi-Drug Resistant and Methicillin Resistant Staphylococcus aureus. Molecules. 24 (3), p. Art. 385. https://doi.org/10.3390/molecules24030385
Total synthesis of acylphloroglucinols and their antibacterial activities against clinical isolates of multi-drug resistant (MDR) and methicillin-resistant strains of Staphylococcus aureus
Rahman, M., Shiu, Winnie K.P., Gibbons, Simon and Malkinson, John P. 2018. Total synthesis of acylphloroglucinols and their antibacterial activities against clinical isolates of multi-drug resistant (MDR) and methicillin-resistant strains of Staphylococcus aureus. European Journal of Medicinal Chemistry. 155, pp. 255-262. https://doi.org/10.1016/j.ejmech.2018.05.038
Anti-Staphylococcal Calopins from Fruiting Bodies of Caloboletus radicans
Tareq, Fakir Shahidullah, Hasan, Choudhury Mahmood, Rahman, M., Hanafi, Mohd Murkish Mohd, Ciacchi, Lucio Colombi, Michaelis, Monika, Harder, Tilmann, Tebben, Jan, Islam, Md. Tofazzal and Spiteller, Peter 2018. Anti-Staphylococcal Calopins from Fruiting Bodies of Caloboletus radicans. Journal of Natural Products. 81 (2), pp. 400-404. https://doi.org/10.1021/acs.jnatprod.7b00525
Analogues of Disulfides from Allium stipitatum Demonstrate Potent Anti-tubercular Activities through Drug Efflux Pump and Biofilm Inhibition
Danquah, Cynthia A., Kakagianni, Eleftheria, Khondkar, Proma, Maitra, Arundhati, Rahman, M., Evangelopoulos, Dimitrios, McHugh, Timothy D., Stapleton, Paul, Malkinson, John, Bhakta, Sanjib and Gibbons, Simon 2018. Analogues of Disulfides from Allium stipitatum Demonstrate Potent Anti-tubercular Activities through Drug Efflux Pump and Biofilm Inhibition. Scientific Reports. 8 (1150). https://doi.org/10.1038/s41598-017-18948-w
Application of computational methods in isolation of plant secondary metabolites
Rahman, M. 2018. Application of computational methods in isolation of plant secondary metabolites. in: Sarker, Satyajit and Nahar, Lutfun (ed.) Computational Phytochemistry Elsevier.
Anti-MRSA Activity of Oxysporone and Xylitol from the Endophytic Fungus Pestalotia sp. Growing on the Sundarbans Mangrove Plant Heritiera fomes
Nurunnabi, Tauhidur Rahman, Nahar, Lutfun, Al-Majmaie, Shaymaa, Mahbubur Rahman, S. M., Sohrab, Md. Hossain, Billah, Md. Morsaline, Ismail, Fyaz M.D., Rahman, M., Sharples, George P. and Sarker, Satyajit D. 2017. Anti-MRSA Activity of Oxysporone and Xylitol from the Endophytic Fungus Pestalotia sp. Growing on the Sundarbans Mangrove Plant Heritiera fomes. Phytotherapy Research. 32 (2), pp. 348-354. https://doi.org/10.1002/ptr.5983
Antimicrobial resistance and synergy in herbal medicine
Mundy, Lorna, Pendry, Barbara and Rahman, M. 2016. Antimicrobial resistance and synergy in herbal medicine. Journal of Herbal Medicine. 6 (2), pp. 53-58. https://doi.org/10.1016/j.hermed.2016.03.001
Antibacterial constituents of Neohyptis paniculata
Rahman, M. and Gibbons, Simon 2015. Antibacterial constituents of Neohyptis paniculata. Fitoterapia. 105, pp. 269-272.
Conversion of salvianolic acid B into salvianolic acid A in tissues of Radix Salviae Miltiorrhizae using high temperature, high pressure and high humidity
Xia, Hongrui, Sun, Longru, Lou, Hongxiang and Rahman, M. 2014. Conversion of salvianolic acid B into salvianolic acid A in tissues of Radix Salviae Miltiorrhizae using high temperature, high pressure and high humidity. Phytomedicine.