Application of computational methods in isolation of plant secondary metabolites

Book chapter

Rahman, M. 2018. Application of computational methods in isolation of plant secondary metabolites. in: Sarker, Satyajit and Nahar, Lutfun (ed.) Computational Phytochemistry Elsevier.
AuthorsRahman, M.
EditorsSarker, Satyajit and Nahar, Lutfun
Abstract

Plant
-
derived secondary metabolites have
made
great contribution
s
to
today’s medicine.
Separation and purification of such metabolites
from a complex mixture
are sometime
s
quite
challenging. The incorporation of computational methods in chromatography
has
facilitated
the separation of
compounds from
a
complex mixtu
re. Such techniques
are automatic,
robust
and offer efficient
separa
tion of secondary metabolites
. This
chapter
highlights the computer
-
aided techniques
associated with
automated
flash chromatography, HPLC, UPLC,
i
on
exchange chromatography,
counter current chromatography and
c
apillary electrophoresis for
the isolation of secondary metabolites. Hyphenated techniques
,
such as
GC
-
MS, LC
-
MS and
L
C
-
NMR
,
have also
been
included for natural product isolation and identification.
S
everal
examples of
isolation of plant
-
derived secon
dary metabolites using computer
-
aided

chromatographic methods
are incorporated
.

Book titleComputational Phytochemistry
Year2018
PublisherElsevier
Publication dates
Print01 May 2018
Publication process dates
Deposited01 Dec 2017
ISBN9780128123645
Web address (URL)https://www.elsevier.com/books/computational-phytochemistry/sarker/978-0-12-812364-5
Permalink -

https://repository.uel.ac.uk/item/84845

Log in to edit

  • 248
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month

Export as

Related outputs

Antileprotic drugs
Shaik, A. B. and Rahman, M. 2023. Antileprotic drugs. in: Acharya, P. C. and Kurosu, M. (ed.) Medicinal Chemistry of Chemotherapeutic Agents: A Comprehensive Resource of Anti-Infective and Anti-cancer Drugs Academic Press. pp. 267-282
Antitubercular drugs
Shaik, A. B. and Rahman, M. 2023. Antitubercular drugs. in: Acharya, P. C. and Kurosu, M. (ed.) Medicinal Chemistry of Chemotherapeutic Agents: A Comprehensive Resource of Anti-Infective and Anti-cancer Drugs Academic Press. pp. 217-265
Bioactivity and In Silico Studies of Isoquinoline and Related Alkaloids as Promising Antiviral Agents: An Insight
Sharma, D., Sharma, N., Manchanda, N., Prasad, S. K., Sharma, P. C., Thakur, V. K., Rahman, M. and Dhobi, M. 2022. Bioactivity and In Silico Studies of Isoquinoline and Related Alkaloids as Promising Antiviral Agents: An Insight. Biomolecules. 13 (1), p. Art. 17. https://doi.org/10.3390/biom13010017
Editorial: Natural products as potential therapeutics to tackle life-threatening infections: From field to market
Rahman, M. 2022. Editorial: Natural products as potential therapeutics to tackle life-threatening infections: From field to market. Frontiers in Pharmacology. 13 (Art. 1099181). https://doi.org/10.3389/fphar.2022.1099181
Antitubercular activity assessment of fluorinated chalcones, 2-aminopyridine-3-carbonitrile and 2-amino-4H-pyran-3-carbonitrile derivatives: In vitro, molecular docking and in-silico drug likeliness studies
Lagu, S. B., Yejella, R. P., Nissankararao, S., Bhandare, R. R., Golla, V. S., Subrahmanya Lokesh, B. V., Rahman, M. and Shaik, A. B. 2022. Antitubercular activity assessment of fluorinated chalcones, 2-aminopyridine-3-carbonitrile and 2-amino-4H-pyran-3-carbonitrile derivatives: In vitro, molecular docking and in-silico drug likeliness studies. PLoS ONE. 17 (Art. e0265068). https://doi.org/10.1371/journal.pone.0265068
Antimicrobial Diterpenes: Recent Development From Natural Sources
Saha, P., Rahman, F. I., Hussain, F., Rahman, S. M. A. and Rahman, M. 2022. Antimicrobial Diterpenes: Recent Development From Natural Sources. Frontiers in Pharmacology. 12 (Art. 820312). https://doi.org/10.3389/fphar.2021.820312
Medicinal plants used to treat infectious diseases in the central part and a northern district of Bangladesh - an ethnopharmacological perception
Siddique, H., Pendry, B., Rashid, M. A. and Rahman, M. 2021. Medicinal plants used to treat infectious diseases in the central part and a northern district of Bangladesh - an ethnopharmacological perception. Journal of Herbal Medicine. 29 (Art. 100484). https://doi.org/10.1016/j.hermed.2021.100484
Anti-MRSA Constituents from Ruta chalepensis (Rutaceae) Grown in Iraq, and In Silico Studies on Two of Most Active Compounds, Chalepensin and 6-Hydroxy-rutin 3’,7-Dimethyl ether
Al-Majmaie, S., Nahar, L., Rahman, M., Nath, S., Saha, P., Talukdar, A. D., Sharples, G. P. and Sarker, S. D. 2021. Anti-MRSA Constituents from Ruta chalepensis (Rutaceae) Grown in Iraq, and In Silico Studies on Two of Most Active Compounds, Chalepensin and 6-Hydroxy-rutin 3’,7-Dimethyl ether. Molecules. 26 (Art. 1114). https://doi.org/10.3390/molecules26041114
Synthesis, and biological screening of chloropyrazine conjugated benzothiazepine derivatives as potential antimicrobial, antitubercular and cytotoxic agents
Shaik, A. B., Bhandare, R. R., Nissankararao, S., Lokesh, B. V. S., Shahanaaz, S. and Rahman, M. 2020. Synthesis, and biological screening of chloropyrazine conjugated benzothiazepine derivatives as potential antimicrobial, antitubercular and cytotoxic agents. Arabian Journal of Chemistry. 14 (Art. 102915). https://doi.org/10.1016/j.arabjc.2020.102915
Design, Facile Synthesis and Characterization of Dichloro Substituted Chalcones and Dihydropyrazole Derivatives for Their Antifungal, Antitubercular and Antiproliferative Activities
Shaik, A. B., Bhandare, R. R., Nissankararao, S., Edis, Z., Tangirala, N. R., Shahanaaz, S. and Rahman, M. 2020. Design, Facile Synthesis and Characterization of Dichloro Substituted Chalcones and Dihydropyrazole Derivatives for Their Antifungal, Antitubercular and Antiproliferative Activities. Molecules. 25 (Art. 3188). https://doi.org/10.3390/molecules25143188
Antimicrobial Natural Products
Rahman, M. and Sarker, S. 2020. Antimicrobial Natural Products. in: Sarker, S. and Nahar, L. (ed.) Medicinal Natural Products: A Disease-Focused Approach, Volume 55 Academic Press. pp. 77-113
Terpenes from Zingiber montanum and Their Screening against Multi-Drug Resistant and Methicillin Resistant Staphylococcus aureus
Siddique, H., Pendry, B. and Rahman, M. 2019. Terpenes from Zingiber montanum and Their Screening against Multi-Drug Resistant and Methicillin Resistant Staphylococcus aureus. Molecules. 24 (3), p. Art. 385. https://doi.org/10.3390/molecules24030385
Total synthesis of acylphloroglucinols and their antibacterial activities against clinical isolates of multi-drug resistant (MDR) and methicillin-resistant strains of Staphylococcus aureus
Rahman, M., Shiu, Winnie K.P., Gibbons, Simon and Malkinson, John P. 2018. Total synthesis of acylphloroglucinols and their antibacterial activities against clinical isolates of multi-drug resistant (MDR) and methicillin-resistant strains of Staphylococcus aureus. European Journal of Medicinal Chemistry. 155, pp. 255-262. https://doi.org/10.1016/j.ejmech.2018.05.038
Antimicrobial Secondary Metabolites—Extraction, Isolation, Identification, and Bioassay
Rahman, M. 2015. Antimicrobial Secondary Metabolites—Extraction, Isolation, Identification, and Bioassay. in: Evidence-Based Validation of Herbal Medicine Elsevier. pp. 495-513
Anti-Staphylococcal Calopins from Fruiting Bodies of Caloboletus radicans
Tareq, Fakir Shahidullah, Hasan, Choudhury Mahmood, Rahman, M., Hanafi, Mohd Murkish Mohd, Ciacchi, Lucio Colombi, Michaelis, Monika, Harder, Tilmann, Tebben, Jan, Islam, Md. Tofazzal and Spiteller, Peter 2018. Anti-Staphylococcal Calopins from Fruiting Bodies of Caloboletus radicans. Journal of Natural Products. 81 (2), pp. 400-404. https://doi.org/10.1021/acs.jnatprod.7b00525
Analogues of Disulfides from Allium stipitatum Demonstrate Potent Anti-tubercular Activities through Drug Efflux Pump and Biofilm Inhibition
Danquah, Cynthia A., Kakagianni, Eleftheria, Khondkar, Proma, Maitra, Arundhati, Rahman, M., Evangelopoulos, Dimitrios, McHugh, Timothy D., Stapleton, Paul, Malkinson, John, Bhakta, Sanjib and Gibbons, Simon 2018. Analogues of Disulfides from Allium stipitatum Demonstrate Potent Anti-tubercular Activities through Drug Efflux Pump and Biofilm Inhibition. Scientific Reports. 8 (1150). https://doi.org/10.1038/s41598-017-18948-w
Anti-MRSA Activity of Oxysporone and Xylitol from the Endophytic Fungus Pestalotia sp. Growing on the Sundarbans Mangrove Plant Heritiera fomes
Nurunnabi, Tauhidur Rahman, Nahar, Lutfun, Al-Majmaie, Shaymaa, Mahbubur Rahman, S. M., Sohrab, Md. Hossain, Billah, Md. Morsaline, Ismail, Fyaz M.D., Rahman, M., Sharples, George P. and Sarker, Satyajit D. 2017. Anti-MRSA Activity of Oxysporone and Xylitol from the Endophytic Fungus Pestalotia sp. Growing on the Sundarbans Mangrove Plant Heritiera fomes. Phytotherapy Research. 32 (2), pp. 348-354. https://doi.org/10.1002/ptr.5983
Antimicrobial resistance and synergy in herbal medicine
Mundy, Lorna, Pendry, Barbara and Rahman, M. 2016. Antimicrobial resistance and synergy in herbal medicine. Journal of Herbal Medicine. 6 (2), pp. 53-58. https://doi.org/10.1016/j.hermed.2016.03.001
Antibacterial constituents of Neohyptis paniculata
Rahman, M. and Gibbons, Simon 2015. Antibacterial constituents of Neohyptis paniculata. Fitoterapia. 105, pp. 269-272.
Conversion of salvianolic acid B into salvianolic acid A in tissues of Radix Salviae Miltiorrhizae using high temperature, high pressure and high humidity
Xia, Hongrui, Sun, Longru, Lou, Hongxiang and Rahman, M. 2014. Conversion of salvianolic acid B into salvianolic acid A in tissues of Radix Salviae Miltiorrhizae using high temperature, high pressure and high humidity. Phytomedicine.