Application of computational methods in isolation of plant secondary metabolites

Book chapter


Rahman, M. 2018. Application of computational methods in isolation of plant secondary metabolites. in: Sarker, Satyajit and Nahar, Lutfun (ed.) Computational Phytochemistry Elsevier.
AuthorsRahman, M.
EditorsSarker, Satyajit and Nahar, Lutfun
Abstract

Plant
-
derived secondary metabolites have
made
great contribution
s
to
today’s medicine.
Separation and purification of such metabolites
from a complex mixture
are sometime
s
quite
challenging. The incorporation of computational methods in chromatography
has
facilitated
the separation of
compounds from
a
complex mixtu
re. Such techniques
are automatic,
robust
and offer efficient
separa
tion of secondary metabolites
. This
chapter
highlights the computer
-
aided techniques
associated with
automated
flash chromatography, HPLC, UPLC,
i
on
exchange chromatography,
counter current chromatography and
c
apillary electrophoresis for
the isolation of secondary metabolites. Hyphenated techniques
,
such as
GC
-
MS, LC
-
MS and
L
C
-
NMR
,
have also
been
included for natural product isolation and identification.
S
everal
examples of
isolation of plant
-
derived secon
dary metabolites using computer
-
aided

chromatographic methods
are incorporated
.

Book titleComputational Phytochemistry
Year2018
PublisherElsevier
Publication dates
Print01 May 2018
Publication process dates
Deposited01 Dec 2017
ISBN9780128123645
Web address (URL)https://www.elsevier.com/books/computational-phytochemistry/sarker/978-0-12-812364-5
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https://repository.uel.ac.uk/item/84845

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