Antitubercular drugs

Book chapter


Shaik, A. B. and Rahman, M. 2023. Antitubercular drugs. in: Acharya, P. C. and Kurosu, M. (ed.) Medicinal Chemistry of Chemotherapeutic Agents: A Comprehensive Resource of Anti-Infective and Anti-cancer Drugs Academic Press. pp. 217-265
AuthorsShaik, A. B. and Rahman, M.
EditorsAcharya, P. C. and Kurosu, M.
Abstract

Tuberculosis (TB) is an infectious illness distressing humanity since ancient times. Every year, the number of cases is rising due to resistance gained by the Mycobacterium tuberculosis (Mtb) strains to the existing antitubercular drugs. They are categorized as first-, second-, or third-line agents based on their discovered and efficacy in therapy. The unregulated use of antitubercular drugs in therapy for years has resulted in multidrug-resistant TB. Here, we discussed the global incidences, pathophysiology of TB and classification, synthetic protocol, mode of action, metabolism, structure–activity relationships, and toxicities of antitubercular drugs. Additionally, a detailed note on drug-resistant TB, solutions to overcome it, and the advances and challenges faced for the discovery of vaccines against drug-resistant TB are discussed. Furthermore, recent advances and the clinical trial status of the antitubercular drugs are summarized. This chapter will help the readers to get a comprehensive overview of antitubercular drugs.

Book titleMedicinal Chemistry of Chemotherapeutic Agents: A Comprehensive Resource of Anti-Infective and Anti-cancer Drugs
Page range217-265
Year2023
PublisherAcademic Press
Publication dates
Online17 Mar 2023
Print27 Mar 2023
Publication process dates
Deposited22 Mar 2023
ISBN9780323905756
Digital Object Identifier (DOI)https://doi.org/10.1016/B978-0-323-90575-6.00003-X
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