Anti-Staphylococcal Calopins from Fruiting Bodies of Caloboletus radicans

Article

Tareq, F. S., Hasan, C. M., Rahman, M., Hanafi, M. M., Ciacchi, L. C., Michaelis, M., Harder, T., Tebben, J., Islam, M. T. and Spiteller, P. 2018. Anti-Staphylococcal Calopins from Fruiting Bodies of Caloboletus radicans. Journal of Natural Products. 81 (2), pp. 400-404. https://doi.org/10.1021/acs.jnatprod.7b00525
AuthorsTareq, F. S., Hasan, C. M., Rahman, M., Hanafi, M. M., Ciacchi, L. C., Michaelis, M., Harder, T., Tebben, J., Islam, M. T. and Spiteller, P.
Abstract

Three new and seven known calopins were isolated from Caloboletus radicans. The structures of the new cyclocalopins, 8-deacetylcyclocalopin B (1), cyclocalopin A-15-ol (2), and 12,15-dimethoxycyclocalopin A (3), were mainly elucidated by NMR and MS data analysis. The stereochemistry of 1–3 was assigned based on ROE correlations, coupling constants and by comparison of their CD spectra with those of similar known calopins. While 1–10 were inactive against two cancer cell lines, they displayed antistaphylococcal activity against methicillin-resistant Staphylococcus aureus strains (MRSA) with MIC values of 16−256 μg/mL. Moreover, some calopins were active against the fish pathogen Enterococcus faecalis F1B1.

JournalJournal of Natural Products
Journal citation81 (2), pp. 400-404
ISSN0163-3864
Year2018
PublisherAmerican Chemical Society with American Society of Pharmacognosy
Accepted author manuscript
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Anyone
Digital Object Identifier (DOI)https://doi.org/10.1021/acs.jnatprod.7b00525
Web address (URL)https://doi.org/10.1021/acs.jnatprod.7b00525
Publication dates
Online30 Jan 2018
Publication process dates
Accepted08 Jan 2018
Deposited25 Jan 2018
FunderDeutsche Forschungsgemeinschaft
Alexander von Humboldt Foundation
Copyright holder© 2018, American Chemical Society and American Society of Pharmacognosy
Additional information

This document is the unedited Author’s version of a Submitted work that was subsequently accepted for publication in Journal of Natural Products, after peer review.

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