Anti-Staphylococcal Calopins from Fruiting Bodies of Caloboletus radicans
Article
Tareq, Fakir Shahidullah, Hasan, Choudhury Mahmood, Rahman, M., Hanafi, Mohd Murkish Mohd, Ciacchi, Lucio Colombi, Michaelis, Monika, Harder, Tilmann, Tebben, Jan, Islam, Md. Tofazzal and Spiteller, Peter 2018. Anti-Staphylococcal Calopins from Fruiting Bodies of Caloboletus radicans. Journal of Natural Products. 81 (2), pp. 400-404. https://doi.org/10.1021/acs.jnatprod.7b00525
Authors | Tareq, Fakir Shahidullah, Hasan, Choudhury Mahmood, Rahman, M., Hanafi, Mohd Murkish Mohd, Ciacchi, Lucio Colombi, Michaelis, Monika, Harder, Tilmann, Tebben, Jan, Islam, Md. Tofazzal and Spiteller, Peter |
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Abstract | Three new and seven known calopins were isolated from Caloboletus radicans. The structures of the new cyclocalopins, 8-deacetylcyclocalopin B (1), cyclocalopin A-15-ol (2), and 12,15-dimethoxycyclocalopin A (3), were mainly elucidated by NMR and MS data analysis. The stereochemistry of 1–3 was assigned based on ROE correlations, coupling constants and by comparison of their CD spectra with those of similar known calopins. While 1–10 were inactive against two cancer cell lines, they displayed antistaphylococcal activity against methicillin-resistant Staphylococcus aureus strains (MRSA) with MIC values of 16−256 μg/mL. Moreover, some calopins were active against the fish pathogen Enterococcus faecalis F1B1. |
Journal | Journal of Natural Products |
Journal citation | 81 (2), pp. 400-404 |
ISSN | 0163-3864 |
Year | 2018 |
Publisher | American Chemical Society with American Society of Pharmacognosy |
Accepted author manuscript | |
Digital Object Identifier (DOI) | https://doi.org/10.1021/acs.jnatprod.7b00525 |
Web address (URL) | https://doi.org/10.1021/acs.jnatprod.7b00525 |
Publication dates | |
Online | 30 Jan 2018 |
Publication process dates | |
Deposited | 25 Jan 2018 |
Accepted | 08 Jan 2018 |
Accepted | 08 Jan 2018 |
Funder | Deutsche Forschungsgemeinschaft |
Alexander von Humboldt Foundation | |
Copyright information | This document is the unedited Author’s version of a Submitted work that was subsequently accepted for publication in Journal of Natural Products, © 2018 American Chemical Society after peer review. All Rights Reserved. |
License | All rights reserved (under embargo) |
https://repository.uel.ac.uk/item/84910
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