The Free-movement pattern Y-maze: A cross-species measure of working memory and executive function

Article


Cleal, M., Fontana, B. D., Ranson, D., McBride, S. D., Swinny, J. D., Redhead, E. S. and Parker, M. O. 2020. The Free-movement pattern Y-maze: A cross-species measure of working memory and executive function. Behavior Research Methods. https://doi.org/10.3758/s13428-020-01452-x
AuthorsCleal, M., Fontana, B. D., Ranson, D., McBride, S. D., Swinny, J. D., Redhead, E. S. and Parker, M. O.
Abstract

Numerous neurodegenerative and psychiatric disorders are associated with deficits in executive functions such as working memory and cognitive flexibility. Progress in developing effective treatments for disorders may benefit from targeting these cognitive impairments, the success of which is predicated on the development of animal models with validated behavioural assays. Zebrafish offer a promising model for studying complex brain disorders, but tasks assessing executive function are lacking. The Free-movement pattern (FMP) Y-maze combines aspects of the common Y-maze assay, which exploits the inherent motivation of an organism to explore an unknown environment, with analysis based on a series of sequential two-choice discriminations. We validate the task as a measure of working memory and executive function by comparing task performance parameters in adult zebrafish treated with a range of glutamatergic, cholinergic and dopaminergic drugs known to impairworking memory and cognitive flexibility. We demonstrate the cross-species validity of the task by assessing performance parameters in adapted versions of the task for mice and Drosophila, and finally a virtual version in humans, and identify remarkable commonalities between vertebrate species’ navigation of the maze. Together, our results demonstrate that the FMP Y-maze is a sensitive assay for assessing working memory and cognitive flexibility across species from invertebrates to humans, providing a simple and widely applicable behavioural assay with exceptional translational relevance.

JournalBehavior Research Methods
ISSN1554-351X
Year2020
PublisherSpringer Nature
Publisher's version
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File Access Level
Anyone
Digital Object Identifier (DOI)https://doi.org/10.3758/s13428-020-01452-x
Web address (URL)https://doi.org/10.3758/s13428-020-01452-x
Publication dates
Online03 Aug 2020
Publication process dates
Accepted07 Jul 2020
Deposited10 Aug 2020
External resourceThe Free-Movement Pattern Y-Maze: The Effective Study Of Working Memory, Exploratory Patterns And Behavioural Plasticity
Copyright holder© 2020 The Authors
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