Pharmacological targeting of the GABAB receptor alters Drosophila's behavioural responses to alcohol

Article


Ranson, D., Ayoub, S., Corcoran, O. and Casalotti, S. 2019. Pharmacological targeting of the GABAB receptor alters Drosophila's behavioural responses to alcohol. Addiction Biology.
AuthorsRanson, D., Ayoub, S., Corcoran, O. and Casalotti, S.
Abstract

When exposed to ethanol, Drosophila melanogaster display a variety of addiction‐like
behaviours similar to those observed in mammals. Sensitivity to ethanol can be quantified by measuring the time at which 50% of the flies are sedated by ethanol exposure
(ST50); an increase of ST50 following multiple ethanol exposures is widely
interpreted as development of tolerance to ethanol. Sensitivity and tolerance to ethanol
were measured after administration of the gamma‐aminobutyric acid receptor B
(GABAB) agonist (SKF 97541) and antagonist (CGP 54626), when compared with flies
treated with ethanol alone. Dose‐dependent increases and decreases in sensitivity to
ethanol were observed for both the agonist and antagonist respectively. Tolerance
was recorded in the presence of GABAB drugs, but the rate of tolerance development
was increased by SKF 97451 and unaltered in presence of CGP 54626. This indicates
that the GABAB receptor contributes to both the sensitivity to ethanol and mechanisms
by which tolerance develops. The data also reinforce the usefulness of Drosophila
as a model for identifying the molecular components of addictive behaviours and
for testing drugs that could potentially be used for the treatment of alcohol use disorder
(AUD).

JournalAddiction Biology
ISSN1355-6215
Year2019
PublisherWiley for Society for the Study of Addiction
Publisher's version
License
Digital Object Identifier (DOI)doi:10.1111/adb.12725
Web address (URL)https://doi.org/10.1111/adb.12725
Publication dates
Online13 Feb 2019
Publication process dates
Deposited13 Feb 2019
Accepted17 Jan 2019
Accepted17 Jan 2019
FunderSociety for the Study of Addiction
Society for the Study of Addiction
Copyright information© 2019 The authors
LicenseCC BY 4.0
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