Characterisation of the signalling mechanisms involved in the induction of cyclooxygenase-2 by interleukin-4
Sivanjaa Manoj, Manoj, Morgan, W. and Ayoub, S. 2016. Characterisation of the signalling mechanisms involved in the induction of cyclooxygenase-2 by interleukin-4. PHARMACOLOGY 2016. The Queen Elizabeth II Conference Centre, London 13 - 15 Dec 2016 London British Pharmacological Society.
|Authors||Sivanjaa Manoj, Manoj, Morgan, W. and Ayoub, S.|
Historically cyclooxygenase (COX)-2 has been associated with the pro-inflammatory phase of inflammation; recently there is evidence to suggest the protein also has an anti-inflammatory role. A number of research groups have given in vivo evidence showing inhibition of COX-2 in the late stages of the inflammatory response to exacerbate inflammation suggesting COX-2 to also play a pro-resolution role1. If proven, this phenomena may open new doors for research as this late phase COX-2 could be considered a target for the early resolution of inflammation. In comparison to lipopolysaccharide (LPS)-stimulated macrophages, we showed diclofenac induced COX-2 was associated with anti-inflammatory cytokine release and required activation of peroxisome proliferator-activated receptor-g (PPAR-g)2. In the current study, we sought to investigate a potential endogenous inducer for the PPAR-g-dependent COX-2 enzyme and to elucidate the molecular pathway associated with induction of this protein.
|Publisher||British Pharmacological Society|
|Accepted author manuscript|
|Publication process dates|
|Deposited||20 Jan 2017|
|Web address (URL)||http://www.pa2online.org/abstract/abstract.jsp?abid=33262&period=64|
|Place of publication||London|
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