Characterisation of the signalling mechanisms involved in the induction of cyclooxygenase-2 by interleukin-4

Conference poster


Sivanjaa Manoj, Manoj, Morgan, W. and Ayoub, S. 2016. Characterisation of the signalling mechanisms involved in the induction of cyclooxygenase-2 by interleukin-4. PHARMACOLOGY 2016. The Queen Elizabeth II Conference Centre, London 13 - 15 Dec 2016 London British Pharmacological Society.
AuthorsSivanjaa Manoj, Manoj, Morgan, W. and Ayoub, S.
TypeConference poster
Abstract

Historically cyclooxygenase (COX)-2 has been associated with the pro-inflammatory phase of inflammation; recently there is evidence to suggest the protein also has an anti-inflammatory role. A number of research groups have given in vivo evidence showing inhibition of COX-2 in the late stages of the inflammatory response to exacerbate inflammation suggesting COX-2 to also play a pro-resolution role1. If proven, this phenomena may open new doors for research as this late phase COX-2 could be considered a target for the early resolution of inflammation. In comparison to lipopolysaccharide (LPS)-stimulated macrophages, we showed diclofenac induced COX-2 was associated with anti-inflammatory cytokine release and required activation of peroxisome proliferator-activated receptor-g (PPAR-g)2. In the current study, we sought to investigate a potential endogenous inducer for the PPAR-g-dependent COX-2 enzyme and to elucidate the molecular pathway associated with induction of this protein.

Year2016
ConferencePHARMACOLOGY 2016
PublisherBritish Pharmacological Society
Accepted author manuscript
License
CC BY
Publication process dates
Deposited20 Jan 2017
CompletedDec 2016
Web address (URL)http://www.pa2online.org/abstract/abstract.jsp?abid=33262&period=64
Place of publicationLondon
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https://repository.uel.ac.uk/item/84y8z

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