Sucrose octasulphate regulates the expression of M1 and M2 macrophage-specific markers in U937 monocytes
Bajwa, P., Garrido Mesa, N., Seed, M. and Ayoub, S. 2019. Sucrose octasulphate regulates the expression of M1 and M2 macrophage-specific markers in U937 monocytes. 14th World Congress on Inflammation 2019. Sydney, AU 15 - 19 Sep 2019 World Congress on Inflammation.
|Authors||Bajwa, P., Garrido Mesa, N., Seed, M. and Ayoub, S.|
Rheumatoid arthritis is driven by an array of cytokines that include TNF-α synthesised by T-cells and macrophages. Sulphated disaccharides are released by heparanase during inflammation to inhibit T-cell function. These compounds, including the synthetic analogue sucrose octasulphate (SOS) were shown to inhibit experimental arthritis in rodents and reduce T-cell function. We have shown that SOS inhibits monocyte-to-macrophage differentiation. The current study was conducted to explore whether SOS can modulate macrophage polarisation into a pro-inflammatory (M1) or anti-inflammatory (M2) phenotype.
|Conference||14th World Congress on Inflammation 2019|
|Publisher||World Congress on Inflammation|
|Publication process dates|
|Completed||16 Sep 2019|
|Deposited||16 Jan 2020|
|Book title||14th World Congress on Inflammation 2019: Abstract Book|
|Web address (URL)||https://wci2019.org/download/WCI%202019%20Abstract%20Book.pdf|
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