Targeting of viral interleukin-10 with an antibody fragment specific to damaged arthritic cartilage improves its therapeutic potency
Hughes, Chris, Sette, Angelica, Seed, M., D’Acquisto, Fulvio, Manzo, Antonio, Vincent, Tonia L, Lim, Ngee and Nissim, Ahuva 2014. Targeting of viral interleukin-10 with an antibody fragment specific to damaged arthritic cartilage improves its therapeutic potency. Arthritis Research & Therapy. 16 (4), p. R151.
|Authors||Hughes, Chris, Sette, Angelica, Seed, M., D’Acquisto, Fulvio, Manzo, Antonio, Vincent, Tonia L, Lim, Ngee and Nissim, Ahuva|
Introduction: We previously demonstrated that a single-chain fragment variable (scFv) specific to collagen type II (CII) posttranslationally modified by reactive oxygen species (ROS) can be used to target anti-inflammatory therapeutics specifically to inflamed arthritic joints. The objective of the present study was to demonstrate the superior efficacy of anti-inflammatory cytokines when targeted to inflamed arthritic joints by the anti-ROS modified CII (anti-ROS-CII) scFv in a mouse model of arthritis.
|Journal||Arthritis Research & Therapy|
|Journal citation||16 (4), p. R151|
|Web address (URL)||http://dx.doi.org/10.1186/ar4613|
|16 Jul 2014|
|Publication process dates|
|Deposited||11 Aug 2014|
|Funder||Arthritis Research Campaign UK|
|Copyright information||© 2014 Hughes et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.|
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