Applying refinement to the use of mice and rats in rheumatoid arthritis research

Article


Hawkins, Penny, Armstrong, Rachel, Boden, Tania, Garside, Paul, Knight, Katherine, Lilley, Elliot, Seed, M., Wilkinson, Michael and Williams, Richard O. 2015. Applying refinement to the use of mice and rats in rheumatoid arthritis research. Inflammopharmacology. 23 (4), pp. 131-150.
AuthorsHawkins, Penny, Armstrong, Rachel, Boden, Tania, Garside, Paul, Knight, Katherine, Lilley, Elliot, Seed, M., Wilkinson, Michael and Williams, Richard O.
Abstract

Rheumatoid arthritis (RA) is a painful, chronic
disorder and there is currently an unmet need for effective
therapies that will benefit a wide range of patients. The
research and development process for therapies and treatments
currently involves in vivo studies, which have the
potential to cause discomfort, pain or distress. This Working
Group report focuses on identifying causes of sufferingwithin
commonly used mouse and rat ‘models’ of RA, describing
practical refinements to help reduce suffering and improve
welfare without compromising the scientific objectives. The
report also discusses other, relevant topics including identifying
and minimising sources of variation within in vivo RA
studies, the potential to provide pain relief including analgesia,
welfare assessment, humane endpoints, reporting
standards and the potential to replace animals in RA research.

JournalInflammopharmacology
Journal citation23 (4), pp. 131-150
ISSN1568-5608
0925-4692
Year2015
PublisherSpringer Verlag
Accepted author manuscript
Web address (URL)http://dx.doi.org/10.1007/s10787-015-0241-4
Publication dates
Print24 Jun 2015
Publication process dates
Deposited27 Jul 2015
Accepted24 Jun 2015
FunderKennedy Trust for Rheumatology Research
European Union
Copyright information© 2015 The authors
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