Animal models of rheumatoid arthritis: How informative are they?
McNamee, Kay, Williams, Richard and Seed, M. 2015. Animal models of rheumatoid arthritis: How informative are they? European Journal of Pharmacology. 759, pp. 278-286.
|Authors||McNamee, Kay, Williams, Richard and Seed, M.|
Animal models of arthritis are widely used to de-convolute disease pathways and to identify novel drug targets and therapeutic approaches. However, the high attrition rates of drugs in Phase II/III rates means that a relatively small number of drugs reach the market, despite showing efficacy in pre-clinical models. There is also increasing awareness of the ethical issues surrounding the use of animal models of disease and it is timely, therefore, to review
|Journal||European Journal of Pharmacology|
|Journal citation||759, pp. 278-286|
|Accepted author manuscript|
|Web address (URL)||http://dx.doi.org/10.1016/j.ejphar.2015.03.047|
|27 Mar 2015|
|Publication process dates|
|Deposited||07 Apr 2015|
|Accepted||12 Mar 2015|
|Copyright information||NOTICE: this is the author’s version of a work that was accepted for publication in European Journal of Pharmacology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in European Journal of Pharmacology, DOI:10.1016/j.ejphar.2015.03.047|
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