Animal models of rheumatoid arthritis: How informative are they?

Article


McNamee, Kay, Williams, Richard and Seed, M. 2015. Animal models of rheumatoid arthritis: How informative are they? European Journal of Pharmacology. 759, pp. 278-286.
AuthorsMcNamee, Kay, Williams, Richard and Seed, M.
Abstract

Animal models of arthritis are widely used to de-convolute disease pathways and to identify novel drug targets and therapeutic approaches. However, the high attrition rates of drugs in Phase II/III rates means that a relatively small number of drugs reach the market, despite showing efficacy in pre-clinical models. There is also increasing awareness of the ethical issues surrounding the use of animal models of disease and it is timely, therefore, to review
the relevance and translatability of animal models of arthritis. In this paper we review the most commonly used animal models in terms of their pathological similarities to human rheumatoid arthritis as well as their response to drug therapy. In general, the ability of animal models to
predict efficacy of biologics in man has been good. However, the predictive power of animal models for small molecules has been variable, probably because of differences in the levels of target knockdown achievable in vivo.

JournalEuropean Journal of Pharmacology
Journal citation759, pp. 278-286
ISSN0014-2999
Year2015
PublisherElsevier
Accepted author manuscript
License
CC BY
Web address (URL)http://dx.doi.org/10.1016/j.ejphar.2015.03.047
Publication dates
Print27 Mar 2015
Publication process dates
Deposited07 Apr 2015
Accepted12 Mar 2015
Copyright informationNOTICE: this is the author’s version of a work that was accepted for publication in European Journal of Pharmacology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in European Journal of Pharmacology, DOI:10.1016/j.ejphar.2015.03.047
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