The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells
Article
Gao, J., Morgan, W., Sanchez-Medina, A. and Corcoran, O. 2011. The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. Toxicology and Applied Pharmacology. 254 (3), pp. 221-228. https://doi.org/10.1016/j.taap.2011.03.016
Authors | Gao, J., Morgan, W., Sanchez-Medina, A. and Corcoran, O. |
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Abstract | Despite a lack of scientific authentication, Scutellaria baicalensis is clinically used in Chinese medicine as a traditional adjuvant to chemotherapy of lung cancer. In this study, cytotoxicity assays demonstrated that crude ethanolic extracts of S. baicalensis were selectively toxic to human lung cancer cell lines A549, SK-LU-1 and SK-MES-1 compared with normal human lung fibroblasts. The active compounds baicalin, baicalein and wogonin did not exhibit such selectivity. Following exposure to the crude extracts, cellular protein expression |
Journal | Toxicology and Applied Pharmacology |
Journal citation | 254 (3), pp. 221-228 |
ISSN | 0041-008X |
Year | 2011 |
Publisher | Elsevier for Academic Press |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.taap.2011.03.016 |
Web address (URL) | https://doi.org/10.1016/j.taap.2011.03.016 |
Publication dates | |
Online | 30 Mar 2011 |
Publication process dates | |
Accepted | 19 Mar 2011 |
Copyright holder | © 2011 Elsevier |
https://repository.uel.ac.uk/item/86y83
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