The Role of Oestrogen Receptor Beta (ERβ) in the Aetiology and Treatment of Type 2 Diabetes Mellitus

Article

Ofosu, W. A., Mohamed, D., Corcoran, O. and Ojo, O. 2019. The Role of Oestrogen Receptor Beta (ERβ) in the Aetiology and Treatment of Type 2 Diabetes Mellitus. Current Diabetes Reviews. 15 (2), pp. 100-104. https://doi.org/10.2174/1573399814666180119141836
AuthorsOfosu, W. A., Mohamed, D., Corcoran, O. and Ojo, O.
Abstract

Introduction: Challenges facing the treatment of type 2 diabetes necessitate the search for agents which act via alternative pathways to provide better therapeutic outcomes. Recently, an increasing body of evidence implicates the activation of oestrogen receptors (ERα and ERβ) in the development and treatment of underlying conditions in type 2 diabetes. This article summarizes available evidence for the involvement of oestrogen receptors in insulin secretion, insulin resistance as well as glucose uptake and highlights the potential of ERβ as a therapeutic target.

Background: Recent studies indicate an association between the activation of each of the isoforms of ER and recent findings indicate that ERβ shows promise as a potential target for antidiabetic drugs. In vitro and in vivo studies in receptor knockout mice indicate beneficial actions of selective agonists of ERβ receptor and underscore its therapeutic potential.

Conclusion: Studies are needed to further elucidate the exact mechanism underlying the role of ERβ activation as a therapeutic approach in the management of type 2 diabetes.

JournalCurrent Diabetes Reviews
Journal citation15 (2), pp. 100-104
ISSN1573-3998
Year2019
PublisherBentham Science Publishers
Accepted author manuscript
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Anyone
Digital Object Identifier (DOI)https://doi.org/10.2174/1573399814666180119141836
Web address (URL)http://www.eurekaselect.com/159214
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Print2019
Publication process dates
Accepted18 Jan 2018
Deposited15 Feb 2019
Copyright holder© 2019 Bentham Science
Copyright informationThe published manuscript is available at EurekaSelect via http://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/1573399814666180119141836.
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