Salvinorin A content in legal high products of Salvia divinorum sold in Mexico

Article


Hernández-Bello, Rafael, García-Rodríguez, Rosa Virginia, García-Sosa, Karlina, Peña-Rodríguez, Luis Manuel, Vázquez-Hernández, Maribel, Ramos-Morales, Fernando Rafael, Corcoran, O. and Alberto, Sánchez-Medina 2015. Salvinorin A content in legal high products of Salvia divinorum sold in Mexico. Forensic Science International. 249 (April), pp. 197-201.
AuthorsHernández-Bello, Rafael, García-Rodríguez, Rosa Virginia, García-Sosa, Karlina, Peña-Rodríguez, Luis Manuel, Vázquez-Hernández, Maribel, Ramos-Morales, Fernando Rafael, Corcoran, O. and Alberto, Sánchez-Medina
Abstract

Salvia divinorum (Lamiaceae) is a herb native to Mexico where is used by Mazatec shamans for spiritual and divination purposes. S. divinorum products are easily available to consumers and are used worldwide as legal highs because of the hallucinogenic effects caused mainly by salvinorin A. Highly popular videos and websites in the internet depicting the use of S. divinorum products have contributed to an increase in their consumption. Recent reports have highlighted the potential of these products to induce psychosis in consumers. In Mexico, dried leaf extracts of S. divinorum are sold in different strengths, claiming to correlate with increasing amounts of salvinorin A. In order to determine the variability of salvinorin A content between brands and to investigate possible correlation between brand strengths, this study sought to quantify salvinorin A in commercial products available in Mexico using an HPLC method. The HPLC analytical method showed a correlation coefficient R2 > 0.99, with LOD of 0.44 μg/mL and LOQ of 1.34 μg/mL. The retention time for salvinorin A was 23.09 ± 0.95 min and the measured concentrations ranged between 8.32 ± 0.65 to 56.52 ± 3.77 mg/g dried leaf. The results for brand c did not show an agreement between the declared and the calculated amount of salvinorin A. Additionally, the emergence in Mexico of high strength salvia products (100x), the lack of regulation and the observed variability of salvinorin A content between brands of commercial legal highs products of S. divinorum could result in a health problem for consumers.

KeywordsLegal highs; HPLC method; Salvia divinorum; salvinorin A
JournalForensic Science International
Journal citation249 (April), pp. 197-201
ISSN03790738
Year2015
PublisherElsevier
Accepted author manuscript
License
CC BY
Accepted author manuscript
License
CC BY
Accepted author manuscript
License
CC BY
Accepted author manuscript
License
CC BY
Accepted author manuscript
License
CC BY
Accepted author manuscript
License
CC BY
Digital Object Identifier (DOI)doi:10.1016/j.forsciint.2015.01.038
Publication dates
Print07 Feb 2015
Publication process dates
Deposited16 Feb 2015
Accepted26 Jan 2015
FunderConsejo Nacional de Ciencia y Tecnología de México
Universidad Veracruzana
Consejo Nacional de Ciencia y Tecnología
Universidad Veracruzana
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