Hit Discovery from Natural Products in Pharmaceutical R&D

Article

Corcoran, O. 2015. Hit Discovery from Natural Products in Pharmaceutical R&D. Encyclopedia of Magnetic Resonance. 4 (2), pp. 455-462. https://doi.org/10.1002/9780470034590.emrstm1432
AuthorsCorcoran, O.
Abstract

The main theoretical and practical aspects of ¹H and ¹³C NMR spectroscopy as relevant to dereplication strategies for natural product hit discovery from plants are summarized, presenting diverse research applications related to pharmaceutical studies. These include advances in pulse sequences for molecular structural characterization of isolated compounds, ¹H NMR spectroscopy metabolomics platforms for screening natural product libraries, miniaturization via microNMR spectroscopy and cryoprobe technologies, hyphenated LC‐NMR‐MS systems with online solid phase extraction and natural product ¹H NMR spectral databases.

JournalEncyclopedia of Magnetic Resonance
Journal citation4 (2), pp. 455-462
ISSN9780470034590
Year2015
PublisherWiley
Digital Object Identifier (DOI)https://doi.org/10.1002/9780470034590.emrstm1432
Web address (URL)https://doi.org/10.1002/9780470034590.emrstm1432
Publication dates
Online14 Jun 2015
Copyright holder© 2015 John Wiley & Sons
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