Hit Discovery from Natural Products in Pharmaceutical R&D
Corcoran, O. 2015. Hit Discovery from Natural Products in Pharmaceutical R&D. Encyclopedia of Magnetic Resonance. 4 (2), pp. 455-462.
The main theoretical and practical aspects of ¹H and ¹³C NMR spectroscopy as relevant to dereplication strategies for natural product hit discovery from plants are summarized, presenting diverse research applications related to pharmaceutical studies. These include advances in pulse sequences for molecular structural characterization of isolated compounds, ¹H NMR spectroscopy metabolomics platforms for screening natural product libraries, miniaturization via microNMR spectroscopy and cryoprobe technologies, hyphenated LC‐NMR‐MS systems with online solid phase extraction and natural product ¹H NMR spectral databases.
|Journal||Encyclopedia of Magnetic Resonance|
|Journal citation||4 (2), pp. 455-462|
|Digital Object Identifier (DOI)||doi:10.1002/9780470034590.emrstm1432|
|Web address (URL)||https://doi.org/10.1002/9780470034590.emrstm1432|
|Online||14 Jun 2015|
|Copyright holder||© 2015 John Wiley & Sons|
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