Acute electronic cigarette use: nicotine delivery and subjective effects in regular users

Article


Dawkins, L. and Corcoran, O. 2014. Acute electronic cigarette use: nicotine delivery and subjective effects in regular users. Psychopharmacology. 231 (2), pp. 401-407. https://doi.org/10.1007/s00213-013-3249-8
AuthorsDawkins, L. and Corcoran, O.
Abstract

Rationale

Electronic cigarettes are becoming increasingly popular among smokers worldwide. Commonly reported reasons for use include the following: to quit smoking, to avoid relapse, to reduce urge to smoke, or as a perceived lower-risk alternative to smoking. Few studies, however, have explored whether electronic cigarettes (e-cigarettes) deliver measurable levels of nicotine to the blood.
Objective

This study aims to explore in experienced users the effect of using an 18-mg/ml nicotine first-generation e-cigarette on blood nicotine, tobacco withdrawal symptoms, and urge to smoke.
Methods

Fourteen regular e-cigarette users (three females), who are abstinent from smoking and e-cigarette use for 12 h, each completed a 2.5 h testing session. Blood was sampled, and questionnaires were completed (tobacco-related withdrawal symptoms, urge to smoke, positive and negative subjective effects) at four stages: baseline, 10 puffs, 60 min of ad lib use and a 60-min rest period.
Results

Complete sets of blood were obtained from seven participants. Plasma nicotine concentration rose significantly from a mean of 0.74 ng/ml at baseline to 6.77 ng/ml 10 min after 10 puffs, reaching a mean maximum of 13.91 ng/ml by the end of the ad lib puffing period. Tobacco-related withdrawal symptoms and urge to smoke were significantly reduced; direct positive effects were strongly endorsed, and there was very low reporting of adverse effects.
Conclusions

These findings demonstrate reliable blood nicotine delivery after the acute use of this brand/model of e-cigarette in a sample of regular users. Future studies might usefully quantify nicotine delivery in relation to inhalation technique and the relationship with successful smoking cessation/harm reduction.

JournalPsychopharmacology
Journal citation231 (2), pp. 401-407
ISSN1432-2072
0033-3158
Year2014
PublisherSpringer
Accepted author manuscript
License
CC BY-ND
Digital Object Identifier (DOI)https://doi.org/10.1007/s00213-013-3249-8
Publication dates
Print01 Jan 2014
Publication process dates
Deposited11 Feb 2014
Copyright informationThe final publication is available at link.springer.com
Permalink -

https://repository.uel.ac.uk/item/85qy6

Download files

Accepted author manuscript
  • 59
    total views
  • 1449
    total downloads
  • 1
    views this month
  • 10
    downloads this month

Export as

Related outputs

Prebiotics may alter bile salt hydrolase activity: Possible implications for cholesterol metabolism
Adebola, O., Corcoran, O. and Morgan, W. 2020. Prebiotics may alter bile salt hydrolase activity: Possible implications for cholesterol metabolism. PharmaNutrition. 12 (Art. 100182). https://doi.org/10.1016/j.phanu.2020.100182
G-protein αq gene expression plays a role in alcohol tolerance in Drosophila melanogaster
Aleyakpo, B., Umukoro, O., Kavlie, R., Ranson, D., Thompsett, A., Corcoran, O. and Casalotti, S. 2019. G-protein αq gene expression plays a role in alcohol tolerance in Drosophila melanogaster. Brain and Neuroscience Advances. 3. https://doi.org/10.1177/2398212819883081
From Scutellaria barbata to BZL101 in Cancer Patients: Phytochemistry, Pharmacology, and Clinical Evidence
Gao, J., Yin, W. and Corcoran, O. 2019. From Scutellaria barbata to BZL101 in Cancer Patients: Phytochemistry, Pharmacology, and Clinical Evidence. Natural Product Communications. 14 (10). https://doi.org/10.1177/1934578X19880645
The Role of Oestrogen Receptor Beta (ERβ) in the Aetiology and Treatment of Type 2 Diabetes Mellitus
Ofosu, W. A., Mohamed, D., Corcoran, O. and Ojo, O. 2019. The Role of Oestrogen Receptor Beta (ERβ) in the Aetiology and Treatment of Type 2 Diabetes Mellitus. Current Diabetes Reviews. 15 (2), pp. 100-104. https://doi.org/10.2174/1573399814666180119141836
Pharmacological targeting of the GABAʙ receptor alters Drosophila's behavioural responses to alcohol
Ranson, D., Ayoub, S., Corcoran, O. and Casalotti, S. 2019. Pharmacological targeting of the GABAʙ receptor alters Drosophila's behavioural responses to alcohol. Addiction Biology. 25 (Art. e12725). https://doi.org/10.1111/adb.12725
Pharmacological Modulation of Alcohol Tolerance via GABA-B receptors in Drosophila melanogaster
Ranson, D., Ayoub, S., Corcoran, O. and Casalotti, S. 2018. Pharmacological Modulation of Alcohol Tolerance via GABA-B receptors in Drosophila melanogaster. 11th FENS Forum of Neuroscience. Berlin, Germany 07 - 11 Jul 2018
Naltrexone Reverses Ethanol Preference and Protein Kinase C Activation in Drosophila melanogaster
Koyyada, Rajeswari, Latchooman, Nilesh, Jonaitis, Julius, Ayoub, S., Corcoran, O. and Casalotti, S. 2018. Naltrexone Reverses Ethanol Preference and Protein Kinase C Activation in Drosophila melanogaster. Frontiers in Physiology. 9 (175), pp. 1-7. https://doi.org/10.3389/fphys.2018.00175
Self-titration by experienced e-cigarette users: blood nicotine delivery and subjective effects (Study Data)
Dawkins, L., Kimber, C., Doig, Mira, Feyerabend, Colin and Corcoran, O. 2018. Self-titration by experienced e-cigarette users: blood nicotine delivery and subjective effects (Study Data). The University of East London. https://doi.org/10.15123/DATA.00000223
Identification and preliminary structure-activity relationship studies of novel pyridyl sulfonamides as potential Chagas disease therapeutic agents
Peres, Raiza Brandão, Ullah, Asma Inam, de Almeida Fiuza, Ludmila Ferreira, Silva, Patricia Bernardino, Batista, Marcos M., Corcoran, O., Reddy, T. and de Nazaré Correia Soeiro, Maria 2018. Identification and preliminary structure-activity relationship studies of novel pyridyl sulfonamides as potential Chagas disease therapeutic agents. Bioorganic & Medicinal Chemistry Letters. 28 (11), pp. 2018-2022. https://doi.org/10.1016/j.bmcl.2018.04.064
Compensatory Puffing With Lower Nicotine Concentration E-liquids Increases Carbonyl Exposure in E-cigarette Aerosols
Kośmider, Leon, Kimber, C., Kurek, Jolanta, Corcoran, O. and Dawkins, Lynne E. 2018. Compensatory Puffing With Lower Nicotine Concentration E-liquids Increases Carbonyl Exposure in E-cigarette Aerosols. Nicotine & Tobacco Research. 20 (8), pp. 998-1003. https://doi.org/10.1093/ntr/ntx162
Synbiotics: the impact of potential prebiotics inulin, lactulose and lactobionic acid on the survival and growth of lactobacilli probiotics
Adebola, Oluwakemi Obasola, Corcoran, O. and Morgan, Winston A. 2014. Synbiotics: the impact of potential prebiotics inulin, lactulose and lactobionic acid on the survival and growth of lactobacilli probiotics. Journal of Functional Foods. 10, pp. 75-84. https://doi.org/10.1016/j.jff.2014.05.010
Silymarin content in Silybum marianum extracts as a biomarker for the quality of commercial tinctures
Pendry, B., Kemp, Virginia, Hughes, Michael J., Freeman, Julia, Nuhu, Hanny K., Sanchez-Medina, Alberto, Corcoran, O. and Galante, Eva 2017. Silymarin content in Silybum marianum extracts as a biomarker for the quality of commercial tinctures. Journal of Herbal Medicine. 10, pp. 31-36. https://doi.org/10.1016/j.hermed.2017.07.001
The Role of G Protein In Alcohol Related Behaviours Using Drosophila melanogaster As A Model
Aleyakpo, B., Umokoro, Oghenetega, Corcoran, O. and Casalotti, S. 2015. The Role of G Protein In Alcohol Related Behaviours Using Drosophila melanogaster As A Model. British Pharmacological Society Annual meeting. London Dec 2015 PA2 online British Pharmacological Society. pp. 307-307
Ethanol-induced G-protein subunit expression changes in D2 receptor deficient Drosophila
Umokoro, Oghenetega, Corcoran, O., Thompsett, Andrew and Casalotti, S. 2015. Ethanol-induced G-protein subunit expression changes in D2 receptor deficient Drosophila. British Neuroscience Association Festival 2015. Edinburgh, UK 12 - 15 Apr 2015 British Neuroscience Association. pp. 297-297
Alcohol gel ingestion amongst homeless Eastern and Central Europeans in London: assessing the effects on cognitive functioning and psychological health
Soar, K., Papaioannou, G. and Dawkins, L. 2016. Alcohol gel ingestion amongst homeless Eastern and Central Europeans in London: assessing the effects on cognitive functioning and psychological health. Substance Use & Misuse. 51 (10), pp. 1274-1282. https://doi.org/10.3109/10826084.2016.1168441
Self-titration by experienced e-cigarette users: blood nicotine delivery and subjective effects
Dawkins, Lynne E., Kimber, Catherine F., Doig, Mira, Feyerabend, Colin and Corcoran, O. 2016. Self-titration by experienced e-cigarette users: blood nicotine delivery and subjective effects. Psychopharmacology. 233 (15), pp. 2933-2941. https://doi.org/10.1007/s00213-016-4338-2
The Effects of E-Cigarette Visual Appearance on Craving and Withdrawal Symptoms in Abstinent Smokers
Dawkins, L., Munafo, Marcus, Christoforou, Gina, Olumegbon, Naomi and Soar, Kirstie 2015. The Effects of E-Cigarette Visual Appearance on Craving and Withdrawal Symptoms in Abstinent Smokers. Psychology of Addictive Behaviours. 30 (1), pp. 101-105. https://doi.org/10.1037/adb0000112
Hit Discovery from Natural Products in Pharmaceutical R&D
Corcoran, O. 2015. Hit Discovery from Natural Products in Pharmaceutical R&D. Encyclopedia of Magnetic Resonance. 4 (2), pp. 455-462. https://doi.org/10.1002/9780470034590.emrstm1432
Salvinorin A content in legal high products of Salvia divinorum sold in Mexico
Hernández-Bello, Rafael, García-Rodríguez, Rosa Virginia, García-Sosa, Karlina, Peña-Rodríguez, Luis Manuel, Vázquez-Hernández, Maribel, Ramos-Morales, Fernando Rafael, Corcoran, O. and Alberto, Sánchez-Medina 2015. Salvinorin A content in legal high products of Salvia divinorum sold in Mexico. Forensic Science International. 249 (April), pp. 197-201. https://doi.org/10.1016/j.forsciint.2015.01.038
First versus second generation electronic cigarettes: predictors of choice and effects on urge to smoke and withdrawal symptoms
Dawkins, L., Kimber, Catherine, Panwanesarasa, Yasothani and Soar, K. 2014. First versus second generation electronic cigarettes: predictors of choice and effects on urge to smoke and withdrawal symptoms. Addiction. 110 (4), pp. 669-677.
Fibroblast growth stimulation, DPPH antioxidant assay and antimicrobial activities of Funtumia elastica (Preuss) Stapf (Apocynaceae) leaf extracts
Osei-Djarbeng, Samuel N., Cutler, S., Cutler, Ronald R. and Corcoran, O. 2014. Fibroblast growth stimulation, DPPH antioxidant assay and antimicrobial activities of Funtumia elastica (Preuss) Stapf (Apocynaceae) leaf extracts. European Journal of Medicinal Plants. 4 (7), pp. 835-843. https://doi.org/10.9734/EJMP/2014/9316
Vaping’ profiles and preferences: an online survey of electronic cigarette users
Dawkins, L. 2013. Vaping’ profiles and preferences: an online survey of electronic cigarette users. UEL Research and Knowledge Exchange Conference 2013. University of East London, London 26 Jun 2013 London University of East London.
‘Vaping’ profiles and preferences: an online survey of electronic cigarette users
Dawkins, L., Turner, J., Roberts, A. and Soar, K. 2013. ‘Vaping’ profiles and preferences: an online survey of electronic cigarette users. Addiction. 108 (6), pp. 1115-1125. https://doi.org/10.1111/add.12150
Nicotine derived from the electronic cigarette improves time-based prospective memory in abstinent smokers
Dawkins, L., Turner, J. and Crowe, Eadaoin 2012. Nicotine derived from the electronic cigarette improves time-based prospective memory in abstinent smokers. Psychopharmacology. 227 (3), pp. 377-384.
Protective effects of prebiotics inulin and lactulose from cytotoxicity and genotoxicity in human colon adenocarcinoma cells
Adebola, O., Corcoran, O. and Morgan, W. 2013. Protective effects of prebiotics inulin and lactulose from cytotoxicity and genotoxicity in human colon adenocarcinoma cells. Food Research International. 52 (1), pp. 269-274. https://doi.org/10.1016/j.foodres.2013.03.024
Anglo-Saxon pharmacopoeia revisited: a potential treasure in drug discovery
Watkins, Frances, Pendry, B., Corcoran, O. and Sanchez-Medina, Alberto 2011. Anglo-Saxon pharmacopoeia revisited: a potential treasure in drug discovery. Drug Discovery Today. 16 (23-24), pp. 1069-1075.
Investigating the impact of nicotine on executive functions using a novel virtual reality assessment
Jansari, A., Froggatt, Daniel, Edginton, Trudi and Dawkins, L. 2012. Investigating the impact of nicotine on executive functions using a novel virtual reality assessment. Addiction. 108 (5), pp. 977-984.
Antimicrobial assays of three native British plants used in Anglo-Saxon medicine for wound healing formulations in 10th century England
Watkins, F., Pendry, B., Sanchez-Medina, A. and Corcoran, O. 2012. Antimicrobial assays of three native British plants used in Anglo-Saxon medicine for wound healing formulations in 10th century England. Journal of Ethnopharmacology. 144 (2), pp. 408-415. https://doi.org/10.1016/j.jep.2012.09.031
Water consumption, not expectancies about water consumption, affects cognitive performance in adults
Edmonds, C., Crombie, Rosanna, Baillieux, Haiko, Gardner, Mark R and Dawkins, L. 2013. Water consumption, not expectancies about water consumption, affects cognitive performance in adults. Appetite. 60, pp. 148-153.
Relapse to smoking during unaided cessation: clinical, cognitive, and motivational predictors
Powell, Jane H, Dawkins, L., West, Robert, Powell, John F and Pickering, Alan 2010. Relapse to smoking during unaided cessation: clinical, cognitive, and motivational predictors. Psychopharmacology. 212 (4), pp. 537-549.
The electronic-cigarette: effects on desire to smoke, withdrawal symptoms and cognition
Dawkins, L., Turner, J., Hasna, Surrayyah and Soar, K. 2012. The electronic-cigarette: effects on desire to smoke, withdrawal symptoms and cognition. Addictive Behaviors. 37 (8), pp. 970-973.
Neuropsychological effects associated with recreational cocaine use
Soar, K., Mason, Colette, Potton, A. and Dawkins, L. 2012. Neuropsychological effects associated with recreational cocaine use. Psychopharmacology. 222 (4), pp. 633-643.
Antimicrobial and anti-quorum sensing activities of some Ghanaian medicinal plants
Osei-Djarbeng, S., Corcoran, O., Cutler, S. and Cutler, R. R. 2012. Antimicrobial and anti-quorum sensing activities of some Ghanaian medicinal plants. International Journal of Indigenous Medicinal Plants. 28 (10), pp. 221-226.
The effects of cigarette smoking and abstinence on auditory verbal learning
Soar, K., Dawkins, L., Begum, H. and Parrott, A.C. 2008. The effects of cigarette smoking and abstinence on auditory verbal learning. Human Psychopharmacology: Clinical and Experimental. 23 (7), pp. 621-627.
Effects of nicotine and alcohol on affective responses to emotionally toned film clips
Dawkins, L. and Powell, J. 2011. Effects of nicotine and alcohol on affective responses to emotionally toned film clips. Psychopharmacology. 216 (2), pp. 197-205.
Expectation of having consumed caffeine can improve performance and mood
Dawkins, L., Shahzad, Fatima-Zahra, Ahmed, Suada S. and Edmonds, C. 2011. Expectation of having consumed caffeine can improve performance and mood. Appetite. 57 (3), pp. 597-600.
The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells
Gao, J., Morgan, W., Sanchez-Medina, A. and Corcoran, O. 2011. The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. Toxicology and Applied Pharmacology. 254 (3), pp. 221-228. https://doi.org/10.1016/j.taap.2011.03.016
Ethnopharmacological survey and in vitro evaluation of wound-healing plants used in South-western Nigeria
Adetutu, A., Morgan, W. and Corcoran, O. 2011. Ethnopharmacological survey and in vitro evaluation of wound-healing plants used in South-western Nigeria. Journal of Ethnopharmacology. 137, pp. 50-56. https://doi.org/10.1016/j.jep.2011.03.073
Smoking, reward responsiveness, and response inhibition: tests of an incentive motivational model
Powell, Jane H., Dawkins, L. and Davis, Robert E. 2002. Smoking, reward responsiveness, and response inhibition: tests of an incentive motivational model. Biological Psychiatry. 51 (2), pp. 151-163.
Cognitive and psychological correlates of smoking abstinence, and predictors of successful cessation
Powell, Jane H., Pickering, Alan D., Dawkins, L., West, Robert and Powell, John F. 2004. Cognitive and psychological correlates of smoking abstinence, and predictors of successful cessation. Addictive Behaviors. 29 (7), pp. 1407-1426.
Patterns of change in withdrawal symptoms, desire to smoke, reward motivation and response inhibition across 3 months of smoking abstinence
Dawkins, L., Powell, Jane H., Pickering, Alan, Powell, John and West, Robert 2009. Patterns of change in withdrawal symptoms, desire to smoke, reward motivation and response inhibition across 3 months of smoking abstinence. Addiction. 104 (5), pp. 850-858.
A double-blind placebo controlled experimental study of nicotine: I - Effects on incentive motivation
Dawkins, L., Powell, Jane H., West, Robert, Powell, John and Pickering, Alan 2006. A double-blind placebo controlled experimental study of nicotine: I - Effects on incentive motivation. Psychopharmacology. 189 (3), pp. 355-367.
The effects of smoking and abstinence on experience of happiness and sadness in response to positively valenced, negatively valenced, and neutral film clips
Dawkins, L., Acaster, Sarah and Powell, Jane H. 2007. The effects of smoking and abstinence on experience of happiness and sadness in response to positively valenced, negatively valenced, and neutral film clips. Addictive Behaviors. 32 (2), pp. 425-431.
A double-blind placebo controlled experimental study of nicotine: II - Effects on response inhibition and executive functioning
Dawkins, L., Powell, Jane H., West, Robert, Powell, John and Pickering, Alan 2007. A double-blind placebo controlled experimental study of nicotine: II - Effects on response inhibition and executive functioning. Psychopharmacology. 190 (4), pp. 457-467.
Secondary metabolite mapping identifies Scutellaria inhibitors of human lung cancer cells
Gao, J., Zhao, H., Hylands, P. J. and Corcoran, O. 2010. Secondary metabolite mapping identifies Scutellaria inhibitors of human lung cancer cells. Journal of Pharmaceutical and Biomedical Analysis. 53 (3), pp. 723-728. https://doi.org/10.1016/j.jpba.2010.04.019
Antibacterial, antioxidant and fibroblast growth stimulation activity of crude extracts of Bridelia ferruginea leaf, a wound-healing plant of Nigeria
Adetutu, A., Morgan, W. and Corcoran, O. 2010. Antibacterial, antioxidant and fibroblast growth stimulation activity of crude extracts of Bridelia ferruginea leaf, a wound-healing plant of Nigeria. Journal of Ethnopharmacology. 133 (1), pp. 116-119. https://doi.org/10.1016/j.jep.2010.09.011
The Learning Gains and Student Perceptions of a Second Life Virtual Lab
Cobb, Stephanie, Heaney, Rose, Corcoran, O. and Henderson-Begg, Stephanie 2009. The Learning Gains and Student Perceptions of a Second Life Virtual Lab. Bioscience Education. https://doi.org/10.3108/beej.13.5
Triterpenoid saponins from a cytotoxic root extract of Sideroxylon foetidissimum subsp. gaumeri
Sanchez-Medina, A., Stevenson, P., Habtemariam, S., Peña-Rodríguez, L. M., Corcoran, O., Mallet, A. L. and Veitch, N. C. 2009. Triterpenoid saponins from a cytotoxic root extract of Sideroxylon foetidissimum subsp. gaumeri. Phytochemistry. 70 (6), pp. 765-772. https://doi.org/10.1016/j.phytochem.2009.03.014