Self-titration by experienced e-cigarette users: blood nicotine delivery and subjective effects

Article


Dawkins, Lynne E., Kimber, Catherine F., Doig, Mira, Feyerabend, Colin and Corcoran, O. 2016. Self-titration by experienced e-cigarette users: blood nicotine delivery and subjective effects. Psychopharmacology. 233 (15), pp. 2933-2941.
AuthorsDawkins, Lynne E., Kimber, Catherine F., Doig, Mira, Feyerabend, Colin and Corcoran, O.
Abstract

Rationale Self-titration is well documented in the tobacco literature. The extent to which ecigarette
users (vapers) self-titrate is unknown.
Objective This study explored the effects of high and low nicotine strength liquid on puffing
topography, nicotine delivery and subjective effects in experienced vapers.
Methods Eleven experienced male vapers completed 60 minutes of ad libitum vaping under
low (6 mg/mL) and high (24 mg/mL) nicotine liquid conditions in two separate sessions.
Measurements included: puffing topography (puff number, puff duration, volume of liquid
consumed); and changes in: plasma nicotine levels, craving, withdrawal symptoms, selfreported
hit, satisfaction and adverse effects.
Results Liquid consumption and puff number were higher, and puff duration longer, in the low
nicotine strength condition (all ps < 0.01). The mean difference in nicotine boost from baseline
in the low condition was 8.59 (7.52) ng/mL, 16.99 (11.72) ng/mL and 22.03 (16.19) ng/mL at
10, 30 and 60 minutes respectively. Corresponding values for the high condition were 33.77
(34.88) ng/mL, 35.48 (28.31) ng/mL and 43.57 (34.78) ng/mL (ps < 0.05). There were no
statistically significant differences between conditions in self-reported craving, withdrawal
symptoms, satisfaction, hit or adverse effects.
Conclusions Vapers engaged in compensatory puffing with lower nicotine strength liquid,
doubling their consumption. Whilst compensatory puffing was sufficient to reduce craving and
withdrawal discomfort, self-titration was incomplete with significantly higher plasma nicotine
levels in the high condition.

JournalPsychopharmacology
Journal citation233 (15), pp. 2933-2941
ISSN1432-2072
0033-3158
Year2016
PublisherSpringer
Accepted author manuscript
License
Digital Object Identifier (DOI)doi:10.1007/s00213-016-4338-2
Publication dates
Print27 May 2016
Publication process dates
Deposited03 Jun 2016
Accepted18 May 2016
FunderUniversity of East London
Underpinning dataSelf-titration by experienced e-cigarette users: blood nicotine delivery and subjective effects (Study Data)
External resourceSelf-titration by experienced e-cigarette users: blood nicotine delivery and subjective effects (Study Data)
Copyright informationThe final publication is available at Springer via http://dx.doi.org/10.1007/s00213-016-4338-2
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