Antimicrobial and anti-quorum sensing activities of some Ghanaian medicinal plants
Osei-Djarbeng, S., Corcoran, O., Cutler, S. and Cutler, R. R. 2012. Antimicrobial and anti-quorum sensing activities of some Ghanaian medicinal plants. International Journal of Indigenous Medicinal Plants. 28 (10), pp. 221-226.
|Authors||Osei-Djarbeng, S., Corcoran, O., Cutler, S. and Cutler, R. R.|
In traditional African medicinal systems, plants are used in treatment of various diseases in which microorganisms are implicated. Some plants claimed to have antimicrobial activities in Ghanaian (African) folklore medicine were investigated for antimicrobial and anti-quorum sensing activities. The aim was to find out if methanol extracts of the plants have antimicrobial activities against some Gram-negative and Gram-positive bacteria, and the yeast-like fungus, Candida albicans. It was also aimed at investigating the potential anti-quorum sensing activities of the plants using Chromobacterium violaceum used as the biomonitor organism. Most of the extracts exhibited minimum inhibitory concentrations of 0.25 – 2mg/ml against most of the microbes employed in the study, using the micro-broth dilution method. In general there was a higher antimicrobial activity against the Gram-positive organisms than the Gram-negatives. On the quorum sensing, many of the extracts exhibited potential anti-quorum sensing activities with diameters of zone of colour inhibition in the range of 10-14mm. In traditional medicine systems, plants used for antibacterial purposes may also have anti-quorum sensing activities, as observed by most of the plant extracts. Anti-quorum sensing activities, which prevent the cell-to-cell communication among bacteria, may contribute to the overall purported antimicrobial activities of the plants.
|Journal||International Journal of Indigenous Medicinal Plants|
|Journal citation||28 (10), pp. 221-226|
|01 Jan 2012|
|Copyright holder||© 2012 Recent Science Publications Archives|
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