Population Structure of East African Relapsing Fever Borrelia spp.

Article

Cutler, S., Bonilla, E. Margarita and Singh, Rajbir J. 2010. Population Structure of East African Relapsing Fever Borrelia spp. Emerging Infectious Diseases. 16 (7), pp. 1076-1080.
AuthorsCutler, S., Bonilla, E. Margarita and Singh, Rajbir J.
Abstract

Differentiation of endemic East African tick-borne relapsing
fever Borrelia duttonii spirochetes from epidemic
louse-borne relapsing fever (LBRF) B. recurrentis spirochetes
into different species has been questioned. We assessed
a noncoding intragenic spacer (IGS) region to compare
genotypes found in clinical samples from relapsing
fever patients. Although IGS typing was highly discriminatory
and resolved 4 East African tick-borne relapsing fever
groups from a disease-endemic region in Tanzania, 2 IGS
clades were found among LBRF patients in Ethiopia. The 2
IGS sequence types for B. recurrentis overlapped with 2 of
the 4 groups found among B. duttonii. All cultivable isolates
of B. duttonii fell into a single IGS cluster, which suggests
their analysis might introduce selective bias. We provide
further support that B. recurrentis is a subset of B. duttonii
and represents an ecotype rather than a species. These observations
have disease control implications and suggest
LBRF Borrelia spp. could reemerge from its tick-borne reservoirs
in which vectors coexist.

Keywordsrecurrent febrile infection; Borrelia spirochetes; lice; ticks; epidemic transmission
JournalEmerging Infectious Diseases
Journal citation16 (7), pp. 1076-1080
ISSN1080-6040
Year2010
Publisher's version
License
CC BY-ND
Web address (URL)http://dx.doi.org/10.3201/eid1607.091085
http://hdl.handle.net/10552/929
Publication dates
PrintJul 2010
Publication process dates
Deposited03 Aug 2010
Additional information

Citation:
Cutler, S.J. Cutler, Bonilla, E.M., Singh, R.J. (2010) ‘Population Structure of East African Relapsing Fever Borrelia spp.’ Emerging Infectious Diseases 16 (7) 1076-1080.

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