Diagnosing Borreliosis
Article
Cutler, S., Rudenko, Nataliia, Golovchenko, Maryna, Cramaro, Wibke J., Kirpach, Josiane, Savic, Sara, Christova, Iva and Amaro, Ana 2017. Diagnosing Borreliosis. Vector-Borne and Zoonotic Diseases. 17 (1), pp. 2-11. https://doi.org/10.1089/vbz.2016.1962
Authors | Cutler, S., Rudenko, Nataliia, Golovchenko, Maryna, Cramaro, Wibke J., Kirpach, Josiane, Savic, Sara, Christova, Iva and Amaro, Ana |
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Abstract | Borrelia species fall into two groups, the Borrelia burgdorferi sensu lato (Bbsl) complex, the cause of Lyme borreliosis (also known as Lyme disease), and the relapsing fever group. Both groups exhibit inter- and intraspecies diversity and thus have variations in both clinical presentation and diagnostic approaches. A further layer of complexity is derived from the fact that ticks may carry multiple infectious agents and are able to transmit them to the host during blood feeding, with potential overlapping clinical manifestations. Besides this, pathogens like Borrelia have developed strategies to evade the host immune system, which allows them to persist within the host, including humans. Diagnostics can be applied at different times during the clinical course and utilize sample types, each with their own advantages and limitations. These differing methods should always be considered in conjunction with potential exposure and compatible clinical features. Throughout this review, we aim to explore different approaches providing the reader with an overview of methods appropriate for various situations. This review will cover human pathogenic members of Bbsl and relapsing fever borreliae, including newly recognized Borrelia miyamotoi spirochetes. |
Journal | Vector-Borne and Zoonotic Diseases |
Journal citation | 17 (1), pp. 2-11 |
ISSN | 1557-7759 |
1530-3667 | |
Year | 2017 |
Publisher | Mary Ann Liebert for Society for Zoonotic Ecology and Epidemiology |
Accepted author manuscript | License |
Digital Object Identifier (DOI) | https://doi.org/10.1089/vbz.2016.1962 |
Publication dates | |
01 Jan 2017 | |
Publication process dates | |
Deposited | 10 Jan 2017 |
Accepted | 01 Dec 2016 |
Funder | European Cooperation in Science and Technology |
Luxembourg Ministry of Research | |
Fonds National de la Recherche Luxembourg | |
Fonds National de la Recherche Luxembourg | |
Copyright information | © 2017 Mary Ann Liebert. Final publication is available from Mary Ann Liebert, Inc., publishers http://dx.doi.org/10.1089/vbz.2016.1962 |
https://repository.uel.ac.uk/item/84x85
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