Fibroblast growth stimulation, DPPH antioxidant assay and antimicrobial activities of Funtumia elastica (Preuss) Stapf (Apocynaceae) leaf extracts

Article

Osei-Djarbeng, Samuel N., Cutler, S., Cutler, Ronald R. and Corcoran, O. 2014. Fibroblast growth stimulation, DPPH antioxidant assay and antimicrobial activities of Funtumia elastica (Preuss) Stapf (Apocynaceae) leaf extracts. European Journal of Medicinal Plants. 4 (7), pp. 835-843. https://doi.org/10.9734/EJMP/2014/9316
AuthorsOsei-Djarbeng, Samuel N., Cutler, S., Cutler, Ronald R. and Corcoran, O.
Abstract

Aims: To investigate the scientific basis for the wound-healing properties of Funtumia elastica (Apocynaceae) leaf extracts using relevant in vitro fibroblast growth stimulation, antimicrobial and DPPH-antioxidant assays.
Place and Duration of Study: School of Health, Sports and Bioscience (Bioscience Laboratories), University of East London in the United Kingdom, between July 2007 and May 2010.
Methodology: Methanolic extract of the leaves, and petroleum ether, ethyl acetate, n- butanol and aqueous fractions partitioned thereof were tested for antimicrobial activities against common wound pathogens (such as Staphylococcus spp, Pseudomonas aeroginosa and Escherichia coli). The Broth dilution method was used to determine the minimum inhibitory concentrations (MIC) of the extracts and fractions. The antioxidant activities were also determined using a 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical assay; whilst the ability to stimulate fibroblast growth was investigated using the MTT (3- [4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide) assay.
Results: The n-butanol fraction exhibited the greatest overall activities. It stimulated the growth of fibroblast cells by 28%, and showed MIC range of 0.13 - 1.0 mg/mL against the Staphylococci species, P. aeruginosa, Bacillus subtilis and E. coli. The non-polar petroleum ether fraction exhibited MICs greater than 2.0 mg/mL against all the organisms. All the fractions exhibited antioxidant activities greater than or comparable to that of ascorbic acid.
Conclusion: Collectively, the antioxidant activity, fibroblast growth stimulation and the antimicrobial activities demonstrated by F. elastica leaf extracts provide some evidence to support the use of the plant to manage wounds in African folklore medicine.

JournalEuropean Journal of Medicinal Plants
Journal citation4 (7), pp. 835-843
ISSN2231-0894
Year2014
PublisherScience Domain International
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Digital Object Identifier (DOI)https://doi.org/10.9734/EJMP/2014/9316
Web address (URL)https://doi.org/10.9734/EJMP/2014/9316
Publication dates
Print29 Mar 2014
Publication process dates
Deposited01 Mar 2019
Accepted23 Mar 2014
Accepted23 Mar 2014
Copyright information© 2014 The authors
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Secondary metabolite mapping identifies Scutellaria inhibitors of human lung cancer cells
Gao, J., Zhao, H., Hylands, P. J. and Corcoran, O. 2010. Secondary metabolite mapping identifies Scutellaria inhibitors of human lung cancer cells. Journal of Pharmaceutical and Biomedical Analysis. 53 (3), pp. 723-728. https://doi.org/10.1016/j.jpba.2010.04.019
Antibacterial, antioxidant and fibroblast growth stimulation activity of crude extracts of Bridelia ferruginea leaf, a wound-healing plant of Nigeria
Adetutu, A., Morgan, W. and Corcoran, O. 2010. Antibacterial, antioxidant and fibroblast growth stimulation activity of crude extracts of Bridelia ferruginea leaf, a wound-healing plant of Nigeria. Journal of Ethnopharmacology. 133 (1), pp. 116-119. https://doi.org/10.1016/j.jep.2010.09.011
The Learning Gains and Student Perceptions of a Second Life Virtual Lab
Cobb, Stephanie, Heaney, Rose, Corcoran, O. and Henderson-Begg, Stephanie 2009. The Learning Gains and Student Perceptions of a Second Life Virtual Lab. Bioscience Education. https://doi.org/10.3108/beej.13.5
The Genome of Borrelia recurrentis, the Agent of Deadly Louse-Borne Relapsing Fever, Is a Degraded Subset of Tick-Borne Borrelia duttonii
Lescot, Magali, Audic, Stéphane, Robert, Catherine, Nguyen, Thi Tien, Blanc, Guillaume, Cutler, S., Wincker, Patrick and Couloux, Arnaud 2008. The Genome of Borrelia recurrentis, the Agent of Deadly Louse-Borne Relapsing Fever, Is a Degraded Subset of Tick-Borne Borrelia duttonii. PLoS Genetics. 4 (9), pp. 1-11. https://doi.org/10.1371/journal.pgen.1000185
Borrelia recurrentis Employs a Novel Multifunctional Surface Protein with Anti-Complement, Anti-Opsonic and Invasive Potential to Escape Innate Immunity
Grosskinsky, Sonja, Schott, Melanie, Brenner, Christiane, Cutler, S., Kraiczy, Peter, Zipfel, Peter F., Simon, Markus M. and Wallich, Reinhard 2009. Borrelia recurrentis Employs a Novel Multifunctional Surface Protein with Anti-Complement, Anti-Opsonic and Invasive Potential to Escape Innate Immunity. PLoS ONE. 4 (3), pp. 1-12.
Triterpenoid saponins from a cytotoxic root extract of Sideroxylon foetidissimum subsp. gaumeri
Sanchez-Medina, A., Stevenson, P., Habtemariam, S., Peña-Rodríguez, L. M., Corcoran, O., Mallet, A. L. and Veitch, N. C. 2009. Triterpenoid saponins from a cytotoxic root extract of Sideroxylon foetidissimum subsp. gaumeri. Phytochemistry. 70 (6), pp. 765-772. https://doi.org/10.1016/j.phytochem.2009.03.014